{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:09:58Z","timestamp":1790226598450,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["826254"],"award-info":[{"award-number":["826254"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB025220\u201002"],"award-info":[{"award-number":["R01EB025220\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["4R00NS102884\u201003"],"award-info":[{"award-number":["4R00NS102884\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cerebrovascular reserve (CVR) reflects the capacity of cerebral blood flow (CBF) to change following a vasodilation challenge. Decreased CVR is associated with a higher stroke risk in patients with cerebrovascular diseases. While revascularization can improve CVR and reduce this risk in adult patients with vasculopathy such as those with Moyamoya disease, its impact on hemodynamics in pediatric patients remains to be elucidated. Arterial spin labeling (ASL) is a quantitative MRI technique that can measure CBF, CVR, and arterial transit time (ATT) non\u2010invasively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the short\u2010 and long\u2010term changes in hemodynamics after bypass surgeries in patients with Moyamoya disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty\u2010six patients (11\u2009months\u201318\u2009years, 28 females) with Moyamoya disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, single\u2010 and multi\u2010delay ASL, T1\u2010weighted, T2\u2010FLAIR, 3D MRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Imaging was performed 2\u2009weeks before and 1\u2009week and 6\u2009months after surgical intervention. Acetazolamide was employed to induce vasodilation during the imaging procedure. CBF and ATT were measured by fitting the ASL data to the general kinetic model. CVR was computed as the percentage change in CBF. The mean CBF, ATT, and CVR values were measured in the regions affected by vasculopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Pre\u2010 and post\u2010revascularization CVR, CBF, and ATT were compared for different regions of the brain. <jats:italic>P<\/jats:italic>\u2010values &lt;0.05 were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ASL\u2010derived CBF in flow territories affected by vasculopathy significantly increased after bypass by 41\u2009\u00b1\u200931% within a week. At 6\u2009months, CBF significantly increased by 51\u2009\u00b1\u200934%, CVR increased by 68\u2009\u00b1\u200933%, and ATT was significantly reduced by 6.6\u2009\u00b1\u20092.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>There may be short\u2010 and long\u2010term improvement in the hemodynamic parameters of pediatric Moyamoya patients after bypass surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28902","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T11:48:56Z","timestamp":1690631336000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short\u2010 and Long\u2010Term <scp>MRI<\/scp> Assessed Hemodynamic Changes in Pediatric Moyamoya Patients After Revascularization"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0210-7739","authenticated-orcid":false,"given":"Moss Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-8178","authenticated-orcid":false,"given":"Elizabeth","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-742X","authenticated-orcid":false,"given":"Rui","family":"Duarte Armindo","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"},{"name":"Department of Neuroradiology Hospital Beatriz \u00c2ngelo  Lisbon 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