{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:58:40Z","timestamp":1791831520969,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["1521Y035"],"award-info":[{"award-number":["1521Y035"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Native T1 and radiomics were used for hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) differentiation previously. The current problem is that global native T1 remains modest discrimination performance and radiomics requires feature extraction beforehand. Deep learning (DL) is a promising technique in differential diagnosis. However, its feasibility for discriminating HCM and HHD has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the feasibility of DL in differentiating HCM and HHD based on T1 images and compare its diagnostic performance with other methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>128 HCM patients (men, 75; age, 50\u2009years\u2009\u00b1\u200916) and 59 HHD patients (men, 40; age, 45\u2009years\u2009\u00b1\u200917).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.<jats:styled-content style=\"fixed-case\">0T<\/jats:styled-content>; Balanced steady\u2010state free precession, phase\u2010sensitive inversion recovery (<jats:styled-content style=\"fixed-case\">PSIR<\/jats:styled-content>) and multislice native <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content> mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Compare HCM and HHD patients baseline data. Myocardial T1 values were extracted from native T1 images. Radiomics was implemented through feature extraction and Extra Trees Classifier. The DL network is ResNet32. Different input including myocardial ring (DL\u2010myo), myocardial ring bounding box (DL\u2010box) and the surrounding tissue without myocardial ring (DL\u2010nomyo) were tested. We evaluate diagnostic performance through AUC of ROC curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Accuracy, sensitivity, specificity, ROC, and AUC were calculated. Independent t test, Mann\u2013Whitney U\u2010test and Chi\u2010square test were adopted for HCM and HHD comparison. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DL\u2010myo, DL\u2010box, and DL\u2010nomyo models showed an AUC (95% confidential interval) of 0.830 (0.702\u20130.959), 0.766 (0.617\u20130.915), 0.795 (0.654\u20130.936) in the testing set. AUC of native T1 and radiomics were 0.545 (0.352\u20130.738) and 0.800 (0.655\u20130.944) in the testing set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The DL method based on T1 mapping seems capable of discriminating HCM and HHD. Considering diagnostic performance, the DL network outperformed the native T1 method. Compared with radiomics, DL won an advantage for its high specificity and automated working mode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28904","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T11:14:10Z","timestamp":1689074050000},"page":"837-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Deep Learning for Discrimination of Hypertrophic Cardiomyopathy and Hypertensive Heart Disease on <scp>MRI<\/scp> Native <scp>T1<\/scp> Maps"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-2136","authenticated-orcid":false,"given":"Zi\u2010Chen","family":"Wang","sequence":"first","affiliation":[{"name":"Ottawa\u2010Shanghai Joint School of Medicine, School of Medicine 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