{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:14:47Z","timestamp":1777072487941,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1305901"],"award-info":[{"award-number":["2016YFC1305901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804500"],"award-info":[{"award-number":["2020YFA0804500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071899"],"award-info":[{"award-number":["82071899"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L182067"],"award-info":[{"award-number":["L182067"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with Cushing's disease, the preoperative identification of pituitary adenomas is crucial to treatment. However, increasing diagnostic accuracy remains an unresolved issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the diagnostic accuracy and the impact of readers' experience regarding high\u2010resolution contrast\u2010enhanced magnetic resonance imaging (hrMRI) for identifying pituitary adenomas in comparison with conventional contrast\u2010enhanced MRI (cMRI) and dynamic contrast\u2010enhanced MRI (dMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Sixty\u2010five patients (median age, 39\u2009years; interquartile range [IQR], 28\u201353\u2009years; 60% females) with treatment\u2010na\u00efve Cushing's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, seven fast spin echo sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The diagnostic accuracies of identifying pituitary adenomas on cMRI, dMRI, combined cMRI and dMRI (cdMRI), and hrMRI were independently evaluated by six readers with three experience levels (high: &gt;20\u2009years, modest: 10\u201320\u2009years, low: &lt;10\u2009years; two readers for each experience level). Readers were asked to localize the lesion, and measure its diameter on the sequence where identified. The reference standard was postoperative histopathology. The impact of readers' experience and interobserver agreement were assessed. Image quality was assessed using a 5\u2010point Likert scale, including overall image quality, sharpness, and structural conspicuity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>McNemar's test, Cochran's test, Wilcoxon signed\u2010rank test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, and <jats:italic>\u03ba<\/jats:italic> statistics for interobserver agreement. A <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For identifying pituitary adenomas (median diameter, 5\u2009mm; IQR, 4\u20135\u2009mm), hrMRI had significantly higher sensitivity (87.7%\u201393.8%) than cMRI, dMRI, and cdMRI (52.3%\u201375.4%) for readers with different experience levels. The interobserver agreement was moderate (<jats:italic>\u03ba<\/jats:italic>\u2009=\u20090.461\u20130.523). The sensitivity for hrMRI was comparable between readers with different experience levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.371). All image quality scores on hrMRI were significantly higher than cMRI and dMRI (5.0 vs. 4.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>For identifying pituitary adenomas in patients with treatment\u2010na\u00efve Cushing's disease, hrMRI may show high diagnostic accuracy and seems not to be affected by readers' experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28975","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T14:50:18Z","timestamp":1693579818000},"page":"2115-2123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three\u2010Dimensional Fast Spin Echo Pituitary <scp>MRI<\/scp> in Treatment\u2010Na\u00efve Cushing's Disease: Reduced Impact of Reader Experience and Increased Diagnostic Accuracy"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-9340","authenticated-orcid":false,"given":"Zeyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"You","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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