{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:10Z","timestamp":1786978090716,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011568","name":"Minist\u00e8re de la Transition \u00e9cologique et Solidaire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung magnetic resonance imaging (MRI) with ultrashort echo\u2010times (UTE\u2010MRI) allows high\u2010resolution and radiation\u2010free imaging of the lung structure in cystic fibrosis (CF). In addition, the combination of elexacaftor\/tezacaftor\/ivacaftor (ETI) has improved CF clinical outcomes such as need for hospitalization. However, the effect on structural disease still needs longitudinal evaluation at high resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze the effects of ETI on lung structural alterations using UTE\u2010MRI, with a focus on bronchiectasis reversibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Fifty CF patients (mean age 24.3\u2009\u00b1\u20099.2; 23 males).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>1.5\u2009T, UTE\u2010MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>All subjects completed both UTE\u2010MRI and pulmonary function tests (PFTs) during two annual visits (M0 and M12), and 30 of them completed a CT scan. They initiated ETI treatment after M0 within a maximum of 3\u2009months from the annual examinations. Three observers scored a clinical MRI Bhalla score on UTE\u2010MRI. Bronchiectasis reversibility was defined as a reduction in both outer and inner bronchial dimensions. Correlations were searched between the Bhalla score and PFT such as the forced expiratory volume in 1\u2009second percentage predicted (FEV1%p).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Comparison was assessed using the paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, correlation using the Spearman correlation test with a significance level of 0.05. Concordance and reproducibility were assessed using intraclass correlation coefficient (ICC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant improvement in MRI Bhalla score after ETI treatment. UTE\u2010MRI demonstrated bronchiectasis reversibility in a subgroup of 18 out of 50 CF patients (36%). These patients with bronchiectasis reversibility were significantly younger, with lower severity of wall thickening but no difference in mucus plugging extent (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.39) was found. The reproducibility of UTE\u2010MRI evaluations was excellent (ICC\u2009\u2265\u20090.95), was concordant with CT scan (N\u2009=\u200930; ICC\u2009\u2265\u20090.90) and significantly correlated to FEV1% at PFT at M0 (N\u2009=\u200950;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.71) and M12 (N\u2009=\u200950;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.72).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>UTE\u2010MRI is a reproducible tool for the longitudinal follow\u2010up of CF patients, allowing to quantify the response to ETI and demonstrating the reversibility of some structural alterations such as bronchiectasis in a substantial fraction of this study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.29041","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:15:57Z","timestamp":1697793357000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Longitudinal Evaluation of Bronchial Changes in Cystic Fibrosis Patients Undergoing Elexacaftor\/Tezacaftor\/Ivacaftor Therapy Using Lung\n                    <scp>MRI<\/scp>\n                    With Ultrashort Echo\u2010Times"],"prefix":"10.1002","volume":"60","author":[{"given":"Mathieu","family":"David","sequence":"first","affiliation":[{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Paediatric Cystic Fibrosis Reference Center (CRCM)  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-9882","authenticated-orcid":false,"given":"Ilyes","family":"Benlala","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Paediatric Cystic Fibrosis Reference Center (CRCM)  Pessac France"},{"name":"Univ. Bordeaux, INSERM Centre de Recherche Cardio\u2010Thoracique de Bordeaux  Pessac France"},{"name":"INSERM, U1045 Centre de Recherche Cardio\u2010Thoracique de Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bui","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Paediatric Cystic Fibrosis Reference Center (CRCM)  Pessac France"},{"name":"Univ. 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