{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:39:54Z","timestamp":1771900794063,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2020YJ0229"],"award-info":[{"award-number":["2020YJ0229"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with repaired tetralogy of Fallot (rTOF) continue to face a heightened risk of deteriorating cardiac function, and quantitative techniques of cardiac MRI\u2010derived cardiac structure and function provide an opportunity to explore the causes and mechanisms of cardiac deterioration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore right\u2013left ventricular interdependence in rTOF patients before and after the onset of right ventricular (RV) heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>One hundred eighteen rTOF patients (21.85 [16.74, 29.20] years, 58 females) and 34 controls (23.5 [21, 26.5] years, 17 females) that underwent cardiac MRI were analyzed, with rTOF patients being further subdivided into those with preserved RV function (N\u2009=\u200954) and those that experienced RV heart failure (N\u2009=\u200964).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T\/balanced steady\u2010state free precession sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>RV, left ventricular (LV), and septal strain; RV and LV volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Chi\u2010squared tests or Fisher's exact test, One\u2010way ANOVAs with Bonferroni's post hoc test, Pearson\/Spearman correlation, and multivariate backward linear regression analysis. A two\u2010tailed <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was deemed as the significance threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MRI\u2010derived RV, LV, and septal strain decreased sequentially in controls, patients with preserved RV function, and patients with RV heart failure, with a good intra\u2010observer (0.909\u20130.964) and inter\u2010observer (0.879\u20130.937) agreement. Correlations between LV and RV strain were found to change sequentially with RV function and were the closest in rTOF patients with RV heart failure (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.270 to 0.506). Correlations between RV volume and septal strain was variable in controls (<jats:italic>r<\/jats:italic>\u2009=\u20090.483 to \u22120.604), patients with preserved RV function (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.034 to \u22120.295), and patients with RV heart failure (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.026 to 0.500). Multivariate analyses revealed that the RV longitudinal strain was independently correlated with LV strain in three directions in rTOF patients with RV heart failure (Radial \u22120.70 [\u22121.33, \u22120.06]; Circumferential 0.44 [0.17, 0.72]; Longitudinal 0.54 [0.26, 0.81]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>In rTOF patients, the coupling between RV volume and septal strain was broken during RV function compensation, and the adverse effect of RV on LV deformation was highest in patients with RV heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29080","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:57:48Z","timestamp":1698148668000},"page":"628-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Right\u2013Left Ventricular Interdependence in Repaired Tetralogy of Fallot Patients With Right Ventricular Heart Failure"],"prefix":"10.1002","volume":"60","author":[{"given":"Li","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3681-6186","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Functional and Molecular Imaging Key Laboratory of 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