{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:56:33Z","timestamp":1783522593451,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A6005"],"award-info":[{"award-number":["U21A6005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ischemia reperfusion injury (IRI)\u2010induced acute kidney injury (AKI) may occur after renal ischemic injury. There is a lack of an accurate and comprehensive detection technique for IRI\u2010AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To longitudinally evaluate IRI\u2010AKI in rats by renal structure, function, and metabolites using multi\u2010parametric MRI (mpMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Forty\u2010eight rats undergoing IRI\u2010AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>7\u2010T, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> mapping, and arterial spin labeling (ASL): echo planar imaging (EPI) sequence; blood oxygen level\u2010dependent (BOLD): gradient recalled echo (GRE) sequence; <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> mapping, quantitative magnetization transfer (qMT), and chemical exchange saturation transfer (CEST): rapid acquisition with relaxation enhancement (RARE) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The mpMRI for IRI\u2010AKI was conducted at 0 (control), 1, 3, 7, 14, and 28\u2009days, all included eight rats. The longitudinal mpMRI signal of manually outlined cortex, outer stripe of the outer medulla (OSOM), inner stripe of the outer medulla, and medulla plus pelvis were calculated and compared, their diagnosis performance for IRI\u2010AKI also been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Pearson correlations analysis for correlation between mpMRI signal and renal injury, unpaired <jats:italic>t<\/jats:italic>\u2010tests for comparing the signal changes, and receiver operating characteristics (ROC) analysis was used to identify most sensitive indicator of mpMRI. A <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with control kidneys, the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values of the cortex and medulla in IRI kidneys increased and reached their highest values on day 14, and the kidneys also showed the most severe edema and segments blurred. The RBF in the cortex and OSOM showed a significant decline after day 3. The BOLD signal in the OSOM largest increased on day 28. The cortical PSR and the amine\u2010CEST both decreased with IRI\u2010AKI progression, and amine\u2010CEST achieved the highest AUC for the diagnosis (0.899).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Multi\u2010parametric MRI may show comprehensive variations in IRI\u2010AKI, and amine\u2010CEST may exhibit the highest accuracy for diagnosis of IRI\u2010AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29094","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:51:16Z","timestamp":1698306676000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Multi\u2010Parametric <scp>MRI<\/scp> for Evaluating Variations in Renal Structure, Function, and Endogenous Metabolites in an Animal Model With Acute Kidney Injury Induced by Ischemia Reperfusion"],"prefix":"10.1002","volume":"60","author":[{"given":"Quan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Zhujiang Hospital Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Medical Image Processing Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Engineering Laboratory for Medical Imaging and Diagnostic Technology Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Medical Image Processing Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Engineering Laboratory for Medical Imaging and Diagnostic Technology Southern Medical University  Guangzhou China"},{"name":"School of 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