{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:15:58Z","timestamp":1789251358600,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020AAA0109503"],"award-info":[{"award-number":["2020AAA0109503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972311\uff0c82141127"],"award-info":[{"award-number":["81972311\uff0c82141127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tertiary lymphoid structures (TLSs) have prognostic value in intrahepatic cholangiocarcinoma (ICC) patients. Noninvasive tool to preoperatively evaluate TLSs is still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the association between TLSs status of ICC and preoperative MRI radiomics analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>One hundred and ninety\u2010two patients with ICC, divided into training (T\u2009=\u2009105), internal validation groups (V1\u2009=\u200946), and external validation group (V2\u2009=\u200941).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sequence<\/jats:title>\n                    <jats:p>Coronal and axial single\u2010shot fast spin\u2010echo T2\u2010weighted, diffusion\u2010weighted imaging, T1\u2010weighted, and T1WI fat\u2010suppressed spoiled gradient\u2010recall echo LAVA sequence at 3.0\u2009T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>The VOIs were drawn manually within the visible borders of the tumors using ITK\u2010SNAP version 3.8.0 software in the axial T2WI, DWI, and portal vein phase sequences. Radiomics features were subjected to least absolute shrinkage and selection operator regression to select the associated features of TLSs and construct the radiomics model. Univariate and multivariate analyses were used to identify the clinical radiological variables associated with TLSs. The performances were evaluated by the area under the receiver operator characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Logistic regression analysis, ROC and AUC, Hosmer\u2013Lemeshow test, Kaplan\u2013Meier method with the log\u2010rank test, calibration curves, and decision curve analysis.\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The AUCs of arterial phase diffuse hyperenhancement were 0.59 (95% confidence interval [CI], 0.50\u20130.67), 0.52 (95% CI, 0.43\u20130.61), and 0.66 (95% CI, 0.52\u20130.80) in the T, V1, and V2 cohorts. The AUCs of Rad\u2010score were 0.85 (95% CI, 0.77\u20130.92), 0.81 (95% CI, 0.67\u20130.94), and 0.84 (95% CI, 0.71\u20130.96) in the T, V1, and V2 cohorts, respectively. In cohort T, low\u2010risk group showed significantly better median recurrence\u2010free survival (RFS)\u00a0than that of the high\u2010risk group, which was also confirmed in cohort V1 and V2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>A preoperative MRI radiomics signature is associated with the intratumoral TLSs status of ICC patients and correlate significantly with RFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.29128","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:40:32Z","timestamp":1699512032000},"page":"715-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association Between\n                    <scp>MRI<\/scp>\n                    Radiomics and Intratumoral Tertiary Lymphoid Structures in Intrahepatic Cholangiocarcinoma and Its Prognostic Significance"],"prefix":"10.1002","volume":"60","author":[{"given":"Ying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, National 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