{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:38:29Z","timestamp":1771472309216,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 20TPA35490311"],"award-info":[{"award-number":["AHA 20TPA35490311"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>MRI\u2010derived left atrial (LA) longitudinal strain has been shown to be a marker for mitral regurgitation, but the utility of LA circumferential strain remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess feasibility and reproducibility of LA circumferential strain, identify changes in mitral regurgitation patients compared to healthy volunteers, and determine strain's association with mitral regurgitation severity and cardiac function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>52 mitral regurgitation patients, 12 healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Steady\u2010state free precession cine and 2D phase contrast sequences at 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Peak LA circumferential strain was computed in each of three short\u2010axis slices (superior, mid, and inferior) and longitudinal strain computed from long\u2010axis slices using MRI feature\u2010tracking software. Strain test\u2013retest reproducibility was determined from two repeat studies in healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>LA circumferential strain test\u2013retest reproducibility was assessed by intra\u2010class correlation coefficient (ICC). Strain was compared between cohorts using Student's <jats:italic>t<\/jats:italic>\u2010test or Mann\u2013Whitney U. Mitral regurgitation severity association with strain and LV function was assessed using Spearman correlation and multivariable regression. Significance was defined as <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LA circumferential strain assessment was feasible in all subjects with moderate reproducibility in the superior (ICC\u2009=\u20090.74), mid LA (ICC\u2009=\u20090.71), and inferior LA (ICC\u2009=\u20090.63). In mitral regurgitation patients, LA circumferential strain was significantly lower in the superior (11.86% [6.5%,19.2%] vs. 18.73%\u2009\u00b1\u20096.7%) and mid LA slices (18.41%\u2009\u00b1\u20099.5% vs. 28.7%\u2009\u00b1\u200910.4%) compared to healthy volunteers. Mitral regurgitation severity significantly associated with mid LA circumferential strain (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.03) and LAV significantly associated with superior LA circumferential strain (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.09), both independent of LA longitudinal strain and CO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> circumferential strain assessment is feasible with moderate reproducibility. Compared to healthy volunteers, patients had significantly lower <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> circumferential strain. Mitral regurgitation severity and <jats:styled-content style=\"fixed-case\">LAV<\/jats:styled-content> were significantly associated with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> circumferential strain independent of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> longitudinal strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29137","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:39:21Z","timestamp":1700678361000},"page":"988-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MRI<\/scp> Quantification of Left Atrial Circumferential Strain in Mitral Regurgitation: A Feasibility and Reproducibility Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2473-3397","authenticated-orcid":false,"given":"Siva P.","family":"Sreedhar","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Chitiboi","sequence":"additional","affiliation":[{"name":"Digital Technology and Innovation Siemens Healthineers  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-7835","authenticated-orcid":false,"given":"Maurice","family":"Pradella","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Department of Radiology, Clinic of Radiology and Nuclear Medicine University Hospital of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed S.M.","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"32","article-title":"Valvular heart disease epidemiology","volume":"10","author":"Aluru JS","year":"2022","journal-title":"Med Sci"},{"key":"e_1_2_7_3_1","first-page":"143","article-title":"ACC\/AHA guideline for the Management of Patients with Valvular Heart Disease: Executive summary: A report of the American College of Cardiology\/American Heart Association joint committee on clinical practice 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