{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:37Z","timestamp":1790352457226,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:00:00Z","timestamp":1700870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Maximum diameter measurements are used to assess the rupture risk of abdominal aortic aneurysms (AAAs); however, these are not precise enough to predict all ruptures. Four\u2010dimensional (4D) flow MRI\u2010derived parameters provide additional information by visualizing hemodynamics in AAAs but merit further investigation before they are clinically applicable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the reproducibility of 4D flow MRI\u2010derived hemodynamics, to investigate possible correlations with lumen and maximum diameter, and to explore potential relationships with vorticity and aneurysm growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective single\u2010arm study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 22 (71.5\u2009\u00b1\u20096.1\u2009years, 20 male) asymptomatic AAA patients with a maximum diameter of at least 30\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3.0\u2009T\/Free\u2010breathing 4D flow MRI phase\u2010contrast acquisition with retrospective ECG\u2010gating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Patients underwent two consecutive 4D flow MRI scans 1\u2010week apart. Aortic volumes were segmented from time\u2010averaged phase contrast magnetic resonance angiographies. Reproducibility was assessed by voxelwise analysis after registration. Mean flow velocity, mean wall shear stress (WSS), mean lumen diameter, and qualitative vorticity scores were assessed. In addition, Dixon MRI and retrospective surveillance data were used to study maximum diameter (including thrombus), intraluminal thrombus volume (ILT), and growth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>For reproducibility assessment, Bland\u2013Altman analyses, Pearson correlation, Spearman's correlation, and orthogonal regression were conducted. Potential correlations between hemodynamics and vorticity scores were assessed using linear regression. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Test\u2013retest median Pearson correlation coefficients for flow velocity and WSS were 0.85 (IQR\u2009=\u20090.08) m\/sec and 0.82 (IQR\u2009=\u20090.10) Pa, respectively. Mean WSS significantly correlated with mean flow velocity (<jats:italic>R<\/jats:italic>\u2009=\u20090.75) and inversely correlated with mean lumen diameter (<jats:italic>R<\/jats:italic>\u2009=\u2009\u22120.73). No significant associations were found between 4D flow MRI\u2010derived hemodynamic parameters and maximum diameter (flow velocity: <jats:italic>P<\/jats:italic>\u2009=\u20090.98, WSS: <jats:italic>P<\/jats:italic>\u2009=\u20090.22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>A 4D flow MRI is robust for assessing the hemodynamics within AAAs. No correlations were found between hemodynamic parameters and maximum diameter, ILT volume and growth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29138","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T10:59:05Z","timestamp":1700909945000},"page":"878-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Four\u2010Dimensional Flow <scp>MRI<\/scp>\u2010Derived Hemodynamics in Abdominal Aortic Aneurysms: Reproducibility and Associations With Diameter, Intraluminal Thrombus Volume, and Vorticity"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-5399","authenticated-orcid":false,"given":"Eva","family":"Aalbregt","sequence":"first","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Radiology and Nuclear Medicine Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Indrakusuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Jalalzadeh","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-4670","authenticated-orcid":false,"given":"R. 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