{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:25:12Z","timestamp":1785007512164,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1312200"],"award-info":[{"award-number":["2018YFC1312200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971614"],"award-info":[{"award-number":["81971614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Resting\u2010state functional MRI (rs\u2010fMRI) has identified static changes of local brain activity among patients with intracerebral hemorrhage (ICH). However, the dynamic and concordance\u2010related characteristics of brain activity remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate static, dynamic, and concordance\u2010related features of the regional brain activity of young non\u2010disabled ICH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010three ICH patients (modified Rankin Scale score \u22642, 21% female, 46.36\u2009\u00b1\u20096.53) and 33 matched healthy controls (HCs) (21% female, 47.64\u2009\u00b1\u20096.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, rs\u2010fMRI using gradient echo\u2010planar imaging, T1\u2010weighted imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Neuropsychological and rs\u2010fMRI data were acquired from all participants. Amplitude of low\u2010frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), voxel\u2010mirrored homotopic connectivity, global signal correlation (GSCorr) and degree centrality (DC), and their dynamic and concordance\u2010related changes with sliding window analysis were calculated based on rs\u2010fMRI data at a whole\u2010brain level. The burden of cerebral small vascular diseases (cSVD) was assessed by cSVD scores. All hemorrhage lesions were delineated on normalized T1 images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Multiple regression models, a voxel\u2010level uncorrected <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, a cluster\u2010level false discovery rate (FDR) corrected <jats:italic>q<\/jats:italic>\u2009&lt;\u20090.05, a re\u2010corrected <jats:italic>q<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;0.05 were considered significant. Pearson or Spearman correlation analyses between fMRI data and neurocognitive performance were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HCs, ICH patients showed significant abnormal changes of ALFF, dynamic ALFF, fALFF, ReHo, dynamic ReHo, GSCorr, DC, and voxel\u2010wise concordance in multiple brain regions mainly including the bilateral cerebellar hemispheres, ipsilesional thalamus, and bilateral middle cingulum gyrus. The ALFF in the cerebellar posterior lobe and thalamus were significantly associated with attention (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.481) and executive function (rho\u2009=\u2009\u22120.521) in ICH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Young non\u2010disabled ICH patients exhibit static, dynamic, and concordance\u2010related alterations of local brain activity, part of which shows associations with cognitive functions.\u00a0These findings may help comprehensively understand the mechanism of cognitive impairment after ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29166","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T09:55:36Z","timestamp":1703584536000},"page":"941-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal Local Brain Activity and Cognitive Impairments in Young <scp>Non\u2010Disabled<\/scp> Patients With Intracerebral Hemorrhage: A <scp>Resting\u2010State<\/scp> Functional <scp>MRI<\/scp> Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3020-5758","authenticated-orcid":false,"given":"Dan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Luo","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Cognitive Neuroscience and Learning, IDG\/McGovern Institute for Brain Research Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Shaocheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Mentougou 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