{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:49:30Z","timestamp":1792705770835,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Background<\/jats:title>Vesical Imaging\u2010Reporting and Data System (VI\u2010RADS) is a pathway for the standardized imaging and reporting of bladder cancer staging using multiparametric (mp) MRI.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To investigate additional role of morphological (MOR) measurements to VI\u2010RADS for the detection of muscle\u2010invasive bladder cancer (MIBC) with mpMRI.<\/jats:p><\/jats:sec>Study Type<\/jats:title>Retrospective.<\/jats:p><\/jats:sec>Population<\/jats:title>A total of 198 patients (72 MIBC and 126 NMIBC) underwent bladder mpMRI was included.<\/jats:p><\/jats:sec>Field Strength\/Sequence<\/jats:title>3.0\u2009T\/T2\u2010weighted imaging with fast\u2010spin\u2010echo sequence, spin\u2010echo\u2010planar diffusion\u2010weighted imaging and dynamic contrast\u2010enhanced imaging with fast 3D gradient\u2010echo sequence.<\/jats:p><\/jats:sec>Assessment<\/jats:title>VI\u2010RADS score and MOR measurement including tumor location, number, stalk, cauliflower\u2010like surface, type of tumor growth, tumor\u2010muscle contact margin (TCM), tumor\u2010longitudinal length (TLL), and tumor cellularity index (TCI) were analyzed by three uroradiologists (3\u2010year, 8\u2010year, and 15\u2010year experience of bladder MRI, respectively) who were blinded to histopathology.<\/jats:p><\/jats:sec>Statistical Tests<\/jats:title>Significant MOR measurements associated with MIBC were tested by univariable and multivariable logistic regression (LR) analysis with odds ratio (OR). Area under receiver operating characteristic curve (AUC) with DeLong's test and decision curve analysis (DCA) were used to compared the performance of unadjusted vs. adjusted VI\u2010RADS. A P<\/jats:italic>\u2010value <0.05 was considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>TCM (OR 9.98; 95% confidence interval [CI] 4.77\u201320.8), TCI (OR 5.72; 95% CI 2.37\u201313.8), and TLL (OR 3.35; 95% CI 1.40\u20138.03) were independently associated with MIBC at multivariable LR analysis. VI\u2010RADS adjusted by three MORs achieved significantly higher AUC (reader 1 0.908 vs. 0.798; reader 2 0.906 vs. 0.855; reader 3 0.907 vs. 0.831) and better clinical benefits than unadjusted VI\u2010RADS at DCA. Specially in VI\u2010RADS\u2010defined equivocal lesions, MOR\u2010based adjustment resulted in 55.5% (25\/45), 70.4% (38\/54), and 46.4% (26\/56) improvement in accuracy for discriminating MIBC in three readers, respectively.<\/jats:p><\/jats:sec>Data Conclusion<\/jats:title>MOR measurements improved the performance of VI\u2010RADS in detecting MIBC with mpMRI, especially for equivocal lesions.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>3<\/jats:p><\/jats:sec>Technical Efficacy<\/jats:title>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29184","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T09:10:46Z","timestamp":1706001046000},"page":"1113-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of Additional MRI<\/scp>\u2010Based Morphologic Measurements on the Performance of VI\u2010RADS<\/scp> for Muscle\u2010Invasive Bladder Cancer"],"prefix":"10.1002","volume":"60","author":[{"given":"Yu","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ling","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Nanjing Medical University Nanjing 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