{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:59:43Z","timestamp":1784026783369,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023CDJYGRH\u2010YB04"],"award-info":[{"award-number":["2023CDJYGRH\u2010YB04"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ\u2010MSX1158"],"award-info":[{"award-number":["CSTB2022NSCQ\u2010MSX1158"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ\u2010MSX0787"],"award-info":[{"award-number":["CSTB2023NSCQ\u2010MSX0787"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Siamese network (SN) using longitudinal DCE\u2010MRI for pathologic complete response (pCR) identification lack a unified approach to phases selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To identify pCR in early\u2010stage NAC, using SN with longitudinal DCE\u2010MRI and introducing IPS for phases selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Multicenter, longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Center A: 162 female patients (50.63\u2009\u00b1\u20098.41\u2009years) divided 7:3 into training and internal validation cohorts. Center B: 61 female patients (50.08\u2009\u00b1\u20097.82\u2009years) were used as an external validation cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Center A: single vendor 3.0\u2009T with a compressed\u2010sensing volume interpolated breath\u2010hold examination sequence. Center B: single vendor 1.5\u2009T with volume interpolated breath\u2010hold examination sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Patients underwent DCE\u2010MRI before and after two NAC cycles, with tumor regions of interest (ROI) manually delineated. Histopathology was the reference for pCR identification. Models developed included a clinical one, four SN models based on IPS\u2010selected phases, and integrated models combining clinical and SN features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Model performance was evaluated using the area under the receiver operating characteristic curve (AUC). The DeLong test was used to compare AUCs. Net reclassification improvement and integrated discrimination improvement (IDI) tests were employed for performance comparison. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In internal and external validation cohorts, the clinical model showed AUCs of 0.760 and 0.718. SN and integrated models, with increasing phases via IPS, achieved AUCs ranging from 0.813 to 0.951 and 0.818 to 0.922. Notably, SN\u20103 and integrated\u20103 and integrated\u20104 outperformed the clinical model. However, input phases beyond 20% did not significantly enhance performance (IDI test: SN\u20104 vs. SN\u20103, <jats:italic>P<\/jats:italic>\u2009=\u20090.314 and 0.630; integrated\u20104 vs. integrated\u20103, <jats:italic>P<\/jats:italic>\u2009=\u20090.785 and 0.709).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The longitudinal multiphase DCE\u2010MRI based on the SN demonstrates promise for identifying pCR in breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 4<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29188","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T18:26:14Z","timestamp":1702923974000},"page":"1325-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early Identification of Pathologic Complete Response to Neoadjuvant Chemotherapy Using Multiphase <scp>DCE\u2010MRI<\/scp> by Siamese Network in Breast Cancer: A Longitudinal Multicenter Study"],"prefix":"10.1002","volume":"60","author":[{"given":"Yao","family":"Huang","sequence":"first","affiliation":[{"name":"School of Medicine, Chongqing University  Chongqing China"},{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Medicine, Chongqing University  Chongqing China"},{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yin","sequence":"additional","affiliation":[{"name":"MR Collaborations, Siemens Healthineers Ltd.  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0239-6988","authenticated-orcid":false,"given":"Jiuquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02510"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.0940"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS21-P2-12-06"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2021.09.025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-11223-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08291-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.2561"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28679"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19933-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2018.10.008"},{"issue":"7","key":"e_1_2_8_15_1","first-page":"18","article-title":"Quantifying tumor heterogeneity via MRI habitats to characterize microenvironmental alterations in HER2+breast cancer","volume":"14","author":"Kazerouni AS","year":"2022","journal-title":"Cancer"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2018.03.039"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.622219"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3502-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143515"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2020.3008040"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2022.3216031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101562"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220389"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192763"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0846-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2019.2956351"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0030"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx397"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3817-9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40537-019-0197-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryai.2020200029"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-022-01580-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08293-y"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101899"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152331"},{"key":"e_1_2_8_36_1","volume-title":"Conference on medical imaging \u2013 computer\u2010aided diagnosis","author":"Ravichandran K","year":"2018"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:29:46Z","timestamp":1731587386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,18]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jmri.29188"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29188","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,18]]},"assertion":[{"value":"2023-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}