{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:59:51Z","timestamp":1776121191574,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS099564"],"award-info":[{"award-number":["R01 NS099564"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pathophysiological changes of Huntington's disease (HD) can precede symptom onset by decades. Robust imaging biomarkers are needed to monitor HD progression, especially before the clinical onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate iron dysregulation and microstructure alterations in subcortical regions as HD imaging biomarkers, and to associate such alterations with motor and cognitive impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fourteen individuals with premanifest HD (38.0\u2009\u00b1\u200911.0\u2009years, 9 females; far\u2010from\u2010onset N\u2009=\u20096, near\u2010onset N\u2009=\u20098), 21 manifest HD patients (49.1\u2009\u00b1\u200912.1\u2009years, 11 females), and 33 age\u2010matched healthy controls (43.9\u2009\u00b1\u200912.2\u2009years, 17 females).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>7\u2009T, T<jats:sub>1<\/jats:sub>\u2010weighted imaging, quantitative susceptibility mapping, and diffusion tensor imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Volume, susceptibility, fractional anisotropy (FA), and mean diffusivity (MD) within subcortical brain structures were compared across groups, used to establish HD classification models, and correlated to clinical measures and cognitive assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Generalized linear model, multivariate logistic regression, receiver operating characteristics with the area under the curve (AUC), and likelihood ratio test comparing a volumetric model to one that also includes susceptibility and diffusion metrics, Wilcoxon paired signed\u2010rank test, and Pearson's correlation. A <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 after Benjamini\u2013Hochberg correction was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher striatal susceptibility and FA were found in premanifest and manifest HD preceding atrophy, even in far\u2010from\u2010onset premanifest HD compared to controls (putamen susceptibility: 0.027\u2009\u00b1\u20090.022 vs. 0.018\u2009\u00b1\u20090.013\u2009ppm; FA: 0.358\u2009\u00b1\u20090.048 vs. 0.313\u2009\u00b1\u20090.039). The model with additional susceptibility, FA, and MD features showed higher AUC compared to volume features alone when differentiating premanifest HD from HC (0.83 vs. 0.66), and manifest from premanifest HD (0.94 vs. 0.83). Higher striatal susceptibility significantly correlated with cognitive deterioration in HD (executive function: <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.600; socioemotional function: <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.486).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>7\u2009T MRI revealed iron dysregulation and microstructure alterations with HD progression, which could precede volume loss, provide added value to HD differentiation, and might be associated with cognitive changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29195","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T18:39:47Z","timestamp":1704998387000},"page":"1484-1499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered Iron and Microstructure in Huntington's Disease Subcortical Nuclei: Insight From 7T MRI"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-1841","authenticated-orcid":false,"given":"Jingwen","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging UCSF  San Francisco California USA"},{"name":"Department of Radiological Sciences UCLA  Los Angeles California USA"},{"name":"Department of Bioengineering UCLA  Los Angeles California 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