{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:37:19Z","timestamp":1768909039972,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871339"],"award-info":[{"award-number":["81871339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271556"],"award-info":[{"award-number":["81271556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7113155"],"award-info":[{"award-number":["7113155"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The alternation of brain white matter (WM) network has been studied in adult spinal cord injury (SCI) patients. However, the WM network alterations in pediatric SCI patients remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate WM network changes and their functional impact in children with thoracolumbar SCI (TSCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010five pediatric patients with TSCI (8.94\u2009\u00b1\u20091.86\u2009years, 8\/27 males\/females) and 34 age\u2010 and gender\u2010matched healthy controls (HCs) participated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T\/DTI imaging using spin\u2010echo echo\u2010planar and T1\u2010weighted imaging using 3D T1\u2010weighted magnetization\u2010prepared rapid gradient\u2010echo sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Pediatric SCI patients were evaluated for motor and sensory scores, injury level, time since injury, and age at injury. The WM network was constructed using a continuous tracing method, resulting in a 90\u2009\u00d7\u200990 matrix. The global and regional metrics were obtained to investigate the alterations of the WM structural network. topology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Two\u2010sample independent <jats:italic>t<\/jats:italic>\u2010tests, chi\u2010squared test, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test, and Spearman correlation. Statistical significance was set at <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, pediatric TSCI patients displayed decreased shortest path length (<jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub>\u2009=\u20091.080\u2009\u00b1\u20090.130) and normalized <jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub> (<jats:italic>\u03bb<\/jats:italic>\u2009=\u20095.020\u2009\u00b1\u20090.363), and increased global efficiency (<jats:italic>E<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.200\u2009\u00b1\u20090.015). Notably, these patients also demonstrated heightened regional properties in the orbitofrontal cortex, limbic system, default mode network, and several audio\u2010visual\u2010related regions. Moreover, the <jats:italic>\u03bb<\/jats:italic> and <jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub> values negatively correlated with sensory scores. Conversely, nodal efficiency values in the right calcarine fissure and surrounding cortex positively correlated with sensory scores. The age at injury positively correlated with node degree in the left parahippocampal gyrus and nodal efficiency in the right posterior cingulate gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Reorganization of the WM networks in pediatric SCI patients is indicated by increased global and nodal efficiency, which may provide promising neuroimaging biomarkers for functional assessment of pediatric SCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29231","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:19:17Z","timestamp":1705727957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Specific Alterations in Brain White Matter Networks and Their Impact on Clinical Function in Pediatric Patients With Thoracolumbar Spinal Cord Injury"],"prefix":"10.1002","author":[{"given":"Beining","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6773","authenticated-orcid":false,"given":"Weimin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain 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