{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:42:05Z","timestamp":1780468925083,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014862","name":"YangZhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["YZ2022094"],"award-info":[{"award-number":["YZ2022094"]}],"id":[{"id":"10.13039\/501100014862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Jiangsu Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["BE2017762"],"award-info":[{"award-number":["BE2017762"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension\u2010induced impairment of the cerebral artery network contributes to cognitive impairment. Characterizing the structure and function of cerebral arteries may facilitate the understanding of hypertension\u2010related pathological mechanisms and lead to the development of new indicators for cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the associations between morphological features of the intracranial arteries distal to the circle of Willis on time\u2010of\u2010flight MRA (TOF\u2010MRA) and cognitive performance in a hypertensive cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>189 hypertensive older males (mean age 64.9\u2009\u00b1\u20097.2\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>TOF\u2010MRA sequence with a 3D spoiled gradient echo readout and arterial spin labeling perfusion imaging sequence with a 3D stack\u2010of\u2010spirals fast spin echo readout at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The intracranial arteries were segmented from TOF\u2010MRA and the total length of distal arteries (TLoDA) and number of arterial branches (NoB) were calculated. The mean gray matter cerebral blood flow (GM\u2010CBF) was extracted from arterial spin labeling perfusion imaging. The cognitive level was assessed with short\u2010term and long\u2010term delay\u2010recall auditory verbal learning test (AVLT) scores, and with montreal cognitive assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Univariable and multivariable linear regression were used to analyze the associations between TLoDA, NoB, GM\u2010CBF and the cognitive assessment scores, with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 indicating significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TLoDA (<jats:italic>r<\/jats:italic>\u2009=\u20090.314) and NoB (<jats:italic>r<\/jats:italic>\u2009=\u20090.346) were significantly correlated with GM\u2010CBF. Multivariable linear regression analyses showed that TLoDA and NoB, but not GM\u2010CBF (<jats:italic>P<\/jats:italic>\u2009=\u20090.272 and 0.141), were significantly associated with short\u2010term and long\u2010term delay\u2010recall AVLT scores. These associations remained significant after adjusting for GM\u2010CBF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The TLoDA and NoB of distal intracranial arteries on TOF\u2010MRA are significantly associated with cognitive impairment in hypertensive subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29242","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T05:34:35Z","timestamp":1706074475000},"page":"1720-1728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of Intracranial Artery Length and Branch Number on Time\u2010of\u2010Flight <scp>MRA<\/scp> With Cognitive Impairment in Hypertensive Older Males"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-2528","authenticated-orcid":false,"given":"Zhensen","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence, Fudan University  Shanghai China"},{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence, Fudan University, Ministry of Education  Shanghai China"},{"name":"Vascular Imaging Lab, Department of Radiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Clinical Medical College, Northern Jiangsu People's Hospital, Yangzhou University  Yangzhou China"},{"name":"Yangzhou Institute of Precision Medicine for Kidney Diseases  Yangzhou 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