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Family Study subjects were scanned using SMS and standard EPI sequences. The biexponential IVIM model was used to estimate fast\u2010diffusion coefficient (<jats:italic>D<\/jats:italic><jats:sub><jats:italic>f<\/jats:italic><\/jats:sub>), fraction of fast diffusion (<jats:italic>f<\/jats:italic>), and slow\u2010diffusion coefficient (<jats:italic>D<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>). Scan time, estimated signal\u2010to\u2010noise ratio (eSNR), eSNR per acquisition, and distortion ratio were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Coefficients of variation (CoV) and Bland Altman analyses were performed for test\u2013retest repeatability. Interclass correlation coefficient (ICC) assessed interobserver agreement with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 deemed significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within\u2010subject CoVs among volunteers (N\u2009=\u200910) for <jats:italic>f<\/jats:italic> and <jats:italic>D<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> were lowest in EPI\u2010NE\u2010LO (11.6%) and SMS\u2010RT\u2010HI (11.1%). Inter\u2010observer ICCs for <jats:italic>f<\/jats:italic> and <jats:italic>D<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> were highest for EPI\u2010NE\u2010LO (0.63) and SMS\u2010RT\u2010LO (0.76). <jats:italic>D<\/jats:italic><jats:sub><jats:italic>f<\/jats:italic><\/jats:sub> could not be estimated for most subjects. Estimated eSNR (EPI\u2009=\u200921.9, SMS\u2009=\u20094.7) and eSNR time (EPI\u2009=\u20096.7, SMS\u2009=\u200916.6) were greater for SMS, with less distortion in the liver region (DR\u2010PE: EPI\u2009=\u200923.6, SMS\u2009=\u200913.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Simultaneous multislice acquisitions had significantly less variability and higher ICCs of <jats:italic>D<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>, higher eSNR, less distortion, and reduced scan time compared to EPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29249","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T09:59:37Z","timestamp":1705658377000},"page":"1691-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reproducibility and Repeatability of Intravoxel Incoherent Motion MRI Acquisition Methods in Liver"],"prefix":"10.1002","volume":"60","author":[{"given":"Juan A.","family":"Vasquez","sequence":"first","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Research Imaging Institute University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center at San Antonio  San Antonio 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