{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:21:50Z","timestamp":1789172510666,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The changes that occur in the gamma\u2010aminobutyric acid (GABA) levels within specific brain regions throughout the day are less clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the daily fluctuations of GABA levels within the parietal lobe (PL) and anterior cingulate gyrus (ACC) regions and explore their association with melatonin (MT) levels, heart rate (HR), and blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>26 healthy young adults (15 males and 11 females aged 22\u201327\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T, T1\u2010weighted imaging, Mescher\u2013Garwood point resolved spectroscopy (MEGA\u2010PRESS) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The acquired GABA signal contained the overlapping signals of macromolecules and homocarnosine, hence expressed as GABA+. The creatine (Cr) signal was applied as an endogenous reference. The GABA+, GABA+\/Cr were measured at six different time points (1:00, 5:00, 9:00, 13:00, 17:00, and 21:00\u2009hours) using MEGA\u2010PRESS. The blood pressure, HR and sputum MT levels, were also acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The one\u2010way repeated\u2010measures analysis of variance (ANOVA) was used to evaluate the GABA, blood pressure, HR, and MT levels throughout the day. A general linear model was used to find the correlation between GABA and blood pressure, HR, and MT. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant variations in GABA+\/Cr and GABA+ levels were observed throughout the day within the PL region. The lowest levels were recorded at 9:00\u2009hour (GABA+\/Cr: 0.100\u2009\u00b1\u20090.003\uff0cGABA+:1.877\u2009\u00b1\u20090.051 i.u) and the highest levels were recorded at 21:00\u2009hour (GABA+\/Cr: 0.115\u2009\u00b1\u20090.003, GABA+:2.122\u2009\u00b1\u20090.052 i.u). The MT levels were positively correlated with GABA+\/Cr (<jats:italic>r<\/jats:italic>\u2009=\u20090.301) and GABA+ (<jats:italic>r<\/jats:italic>\u2009=\u20090.312) within the ACC region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>GABA+\/Cr and GABA+ in ACC are positively correlated with MT. GABA levels in the PL have diurnal differences. These findings may indicate that the body's GABA level change in response to the light\u2013dark cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29255","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T12:59:36Z","timestamp":1706533176000},"page":"1500-1511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>MR<\/scp> Spectroscopy Assessment of Daily Variations of <scp>GABA<\/scp> Levels within the Parietal Lobe and Anterior Cingulate Gyrus Regions of Healthy Young Adults"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5137-7574","authenticated-orcid":false,"given":"Yujie","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Radiology First 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