{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:59:46Z","timestamp":1787313586224,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271971"],"award-info":[{"award-number":["82271971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCYBJC01640"],"award-info":[{"award-number":["21JCYBJC01640"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCQNJC01840"],"award-info":[{"award-number":["21JCQNJC01840"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCYBJC01290"],"award-info":[{"award-number":["21JCYBJC01290"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum creatinine (Scr) may be not suited to timely and accurately reflect kidney injury related to chronic liver disease. Currently, the ability of arterial spin labeling (ASL) and blood oxygen level\u2010dependent (BOLD) sequences to evaluate renal blood flow (RBF) and blood oxygen in chronic liver disease remains to be verified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the value of ASL and BOLD imaging in evaluating hemodynamics and oxygenation changes during kidney injury in an animal model of chronic liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animal Model<\/jats:title>\n                    <jats:p>Chronic liver disease model was established by subcutaneous injection of carbon tetrachloride. Forty\u2010three male Sprague\u2013Dawley rats (8\u2009weeks) were divided into a pathological group (0, 2, 4, 6, 8, 12\u2009weeks, each group: N\u2009=\u20096) and a continuous\u2010scanning group (N\u2009=\u20097).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2010T, ASL, BOLD, and T2W.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Regions of interest in the cortex (CO), outer stripe of the outer medulla (OSOM), and inner stripe of the outer medulla (ISOM) are manually delineated. The RBF and T2* values at each time point (0, 2, 4, 6, 8, 12\u2009weeks) are measured and compared. Hematoxylin\u2013eosin score (HE Score, damage area scoring method), alpha\u2010smooth muscle actin (\u03b1\u2010SMA), hypoxia\u2010inducible factor\u20101alpha (HIF\u20101\u03b1), peritubular capillar (PTC) density, Scr, and neutrophil gelatinase\u2010associated lipocalin were harvested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Analysis of variance, Spearman correlation analysis, Kruskal\u2013Wallis tests, and receiver operating characteristic analysis with the area under the curve (AUC). A\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value &lt;0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Renal RBF and T2* values of CO, OSOM, and ISOM were significantly different from baseline. Both RBF and T2* were significantly correlated with HE Score, \u03b1\u2010SMA, HIF\u20101\u03b1, and PTC density (|\n                      <jats:italic>r<\/jats:italic>\n                      |\u2009=\u20090.406\u20130.853). RBF demonstrated superior diagnostic capability in identifying severe kidney injury in this model of chronic liver disease (AUC\u2009=\u20090.964).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Imaging by ASL and BOLD may detect renal hemodynamics and oxygenation changes related to chronic liver disease early.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>5<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.29265","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:19:31Z","timestamp":1706775571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Kidney Injury Using Arterial Spin Labeling and Blood Oxygen Level\u2010Dependent MRI: An Experimental Study in Rats With Carbon Tetrachloride\u2010Induced Liver Cirrhosis"],"prefix":"10.1002","author":[{"given":"Jiaming","family":"Qin","sequence":"first","affiliation":[{"name":"The School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-6516","authenticated-orcid":false,"given":"Shuangshuang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin First Central Hospital Tianjin Institute of Imaging Medicine  Tianjin 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