{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:29:14Z","timestamp":1772666954720,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108015"],"award-info":[{"award-number":["82120108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with restrictive cardiomyopathy (RCM) have impaired diastolic filling and hemodynamic congestion. Pulmonary transit time (PTT) and pulmonary blood volume index (PBVi) reflect the hemodynamic status, but the relationship with left ventricle (LV) dysfunction remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the PTT and PBVi in RCM patients, the association with diastolic dysfunction and LV deformation, and the effects on the occurrence of major adverse cardiac events (MACE) in RCM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>137 RCM patients (88 men, age 58.80\u2009\u00b1\u200910.83\u2009years) and 68 age\u2010 and sex\u2010matched controls (46 men, age 57.00\u2009\u00b1\u20098.59\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T\/Balanced steady\u2010state free precession sequence, recovery prepared echo\u2010planar imaging sequence, and phase\u2010sensitive inversion recovery sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The LV function and peak strain (PS) parameters were measured. The PTT was calculated and corrected by heart rate (PTTc). The PBVi was calculated as the product of PTTc and RV stroke volume index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Chi\u2010squared test, student's <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney U test, Pearson's or Spearman's correlation, multivariate linear regression, Kaplan\u2013Meier survival analysis, and Cox regression models analysis. A <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PTTc showed a significant correlation with the <jats:italic>E<\/jats:italic>\/<jats:italic>A<\/jats:italic> ratio (<jats:italic>r<\/jats:italic>\u2009=\u20090.282), and PBVi showed a significant correlation with the <jats:italic>E<\/jats:italic>\/<jats:italic>e<\/jats:italic>\u2032 ratio, <jats:italic>E<\/jats:italic>\/<jats:italic>A<\/jats:italic> ratio, and diastolic dysfunction stage (<jats:italic>r<\/jats:italic>\u2009=\u20090.222, 0.320, and 0.270). PTTc showed an independent association with LVEF, LV circumferential PS, and LV longitudinal PS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.472, 0.299, and\u20090.328). In Kaplan\u2013Meier analysis, higher PTTc and PBVi were significantly associated with MACE. In multivariable Cox regression analysis, PTTc was a significantly independent predictor of the MACE in combination with both cardiac MRI functional and tissue parameters (hazard ratio: 1.23\/1.32, 95% confidence interval: 1.10\u20131.42\/1.20\u20131.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>PTTc and PBVi are associated with diastolic dysfunction and deteriorated LV deformation, and PTTc independently predicts MACE in patients with RCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29283","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:24:06Z","timestamp":1707917046000},"page":"2343-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Pulmonary Transit Time and Pulmonary Blood Volume From First\u2010Pass Perfusion Cardiac <scp>MRI<\/scp> With Diastolic Dysfunction and Left Ventricle Deformation in Restrictive Cardiomyopathy"],"prefix":"10.1002","volume":"60","author":[{"given":"Yue","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yan","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of 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