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Moreover, existing studies on nurses with burnout are limited by their cross\u2010sectional design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate rich club reorganization in nursing staff before and after the onset of burnout and the underlying impact of anatomical distance on such reconfiguration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Thirty\u2010nine hospital nurses ( years old at baseline,  years old at a follow\u2010up within 1.5\u2009years, 38 female).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Magnetization\u2010prepared rapid gradient\u2010echo and gradient\u2010echo echo\u2010planar imaging sequences at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The Maslach Burnout Inventory and Symptom Check\u2010List 90 testing were acquired at each MRI scan. Rich club structure was assessed at baseline and follow\u2010up to determine whether longitudinal changes were related to burnout and to changes in connectivities with different anatomical distances (short\u2010, mid\u2010, and long range).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Chi\u2010square, paired\u2010samples <jats:italic>t<\/jats:italic>, two\u2010sample <jats:italic>t<\/jats:italic>, Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests, network\u2010based statistic, Spearman correlation analysis, and partial least squares regression analysis. Significance level: Bonferroni\u2010corrected .<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In nurses who developed burnout: 1) Strengths of rich club, feeder, local, short\u2010, mid\u2010, and long\u2010range connectivities were significantly decreased at follow\u2010up compared with baseline. 2) At follow\u2010up, strengths of above connectivities and that between A5m.R and dlPu.L were significantly correlated with emotional exhaustion (<jats:italic>r<\/jats:italic> ranges from \u22120.57 to \u22120.73) and anxiety scores (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.56), respectively. 3) Longitudinal change (follow\u2010up minus baseline) in connectivity strength between A5m.R and dlPu.L reflected change in emotional exhaustion score (<jats:italic>r<\/jats:italic>\u2009=\u20090.87). Longitudinal changes in strength of connectivities mainly involving parietal lobe were significantly decreased in nurses who developed burnout compared with those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>In nurses after the onset of burnout, rich club reorganization corresponded to significant reductions in strength of connectivities with different anatomical distances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29288","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:33:55Z","timestamp":1707917635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rich Club Reorganization in Nurses Before and After the Onset of Occupational Burnout: A Longitudinal 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