{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:17:46Z","timestamp":1783534666496,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with bicuspid aortic valve (BAV), 4D flow MRI can quantify regions exposed to abnormal aortic hemodynamics, including high wall shear stress (WSS), a known stimulus for arterial wall dysfunction. However, the long\u2010term multiscan reproducibility of 4D flow MRI\u2010derived hemodynamic parameters is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the long\u2010term stability of 4D flow MRI\u2010derived peak velocity, WSS, and WSS\u2010derived heatmaps in patients with BAV undergoing multiyear surveillance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>20 BAV patients (mean age 48.4\u2009\u00b1\u200913.9\u2009years; 14 males) with five 4D flow MRI scans, with intervals of at least 6 months between scans, and 125 controls (mean age: 50.7\u2009\u00b1\u200915.8\u2009years; 67 males).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5 and 3.0T, prospectively ECG and respiratory navigator\u2010gated aortic 4D flow MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Automated AI\u2010based 4D flow analysis pipelines were used for data preprocessing, aorta 3D segmentation, and quantification of ascending aorta (AAo) peak velocity, peak systolic WSS, and heatmap\u2010derived relative area of elevated WSS compared to WSS ranges in age and sex\u2010matched normative control populations. Growth rate was derived from the maximum AAo diameters measured on the first and fifth MRI scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way repeated measures analysis of variance. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 indicated significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred 4D flow MRI exams (five per patient) were analyzed. The mean total follow\u2010up duration was 5.5\u2009\u00b1\u20091.1\u2009years, and the average growth rate was 0.3\u2009\u00b1\u20090.2\u2009mm\/year. Peak velocity, peak systolic WSS, and relative area of elevated WSS did not change significantly over the follow\u2010up period (<jats:italic>P<\/jats:italic>\u2009=\u20090.64, <jats:italic>P<\/jats:italic>\u2009=\u20090.69, and <jats:italic>P<\/jats:italic>\u2009=\u20090.35, respectively). The patterns and areas of elevated WSS demonstrated good reproducibility on semiquantitative assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>4D flow MRI\u2010derived peak velocity, WSS, and WSS\u2010derived heatmaps showed good multiyear and multiscan stability in BAV patients with low aortic growth rates. These findings underscore the reliability of these metrics in monitoring BAV patients for potential risk of dilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29305","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T12:14:21Z","timestamp":1709295261000},"page":"2580-2589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multiyear Interval Changes in Aortic Wall Shear Stress in Patients with Bicuspid Aortic Valve Assessed by <scp>4D<\/scp> Flow <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-6008","authenticated-orcid":false,"given":"Anthony","family":"Maroun","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Catania","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haben","family":"Berhane","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-5541","authenticated-orcid":false,"given":"Kelly","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of 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