{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:31:28Z","timestamp":1769747488115,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201005708"],"award-info":[{"award-number":["RGPIN\u20102019\u201005708"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intrauterine growth restriction (IUGR) is an obstetrical condition where a fetus has not achieved its genetic potential. A consequence of IUGR is a decrease in brain myelin content. Myelin water imaging (MWI) has been used to assess fetal myelin water fraction (MWF) and might potentially assess myelination changes associated with IUGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To quantify and compare the MWF of non\u2010IUGR and IUGR fetal guinea pigs (GPs) in late gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Dunkin\u2010Hartley GP model of spontaneous IUGR (mean\u2009\u00b1\u2009SD: 60\u2009\u00b1\u20091.2\u2009days gestation; 19 IUGR, 52 control).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Eight spoiled gradient\u2010recalled (SPGR) gradient echo volumes (flip angles [<jats:italic>\u03b1<\/jats:italic>]: 2\u00b0\u201316\u00b0), and two sets of eight balanced steady\u2010state free precession (bSSFP) gradient echo volumes (<jats:italic>\u03b1<\/jats:italic>: 8\u00b0 \u2013 64\u00b0), at 0\u00b0 and 180\u00b0 phase increments, at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>MWF maps were generated for each fetal GP brain using multicomponent driven equilibrium single pulse observation of T<jats:sub>1<\/jats:sub>\/T<jats:sub>2<\/jats:sub> (mcDESPOT). MWF was quantified in the fetal corpus callosum (CC), fornix (FOR), parasagittal white matter (PSW), and whole fetal brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Linear regression was performed between five fetal IUGR markers (body volume, body\u2010to\u2010pregnancy volume ratio, brain\u2010to\u2010liver volume ratio, brain\u2010to\u2010placenta volume ratio, and brain\u2010to\u2010body volume ratio) and MWF (coefficient of determination, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>). A <jats:italic>t<\/jats:italic>\u2010test with a linear mixed model compared the MWF of non\u2010IUGR and IUGR fetal GPs (significance was determined at <jats:italic>\u03b1<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MWF of the control fetuses are (mean\u2009\u00b1\u2009SD): 0.23\u2009\u00b1\u20090.02 (CC), 0.31\u2009\u00b1\u20090.02 (FOR), 0.28\u2009\u00b1\u20090.02 (PSW), and 0.20\u2009\u00b1\u20090.01 (whole brain). The MWF of the IUGR fetuses are (mean\u2009\u00b1\u2009SD): 0.19\u2009\u00b1\u20090.02 (CC), 0.27\u2009\u00b1\u20090.01 (FOR), 0.24\u2009\u00b1\u20090.03 (PSW), and 0.16\u2009\u00b1\u20090.01 (whole brain). Significant differences in MWF were found between the non\u2010IUGR and IUGR fetuses in every comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The mean MWF of IUGR fetal GPs is significantly lower than non\u2010IUGR fetal GPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29332","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T13:38:57Z","timestamp":1709732337000},"page":"2615-2625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantifying Brain Myelin Water Fraction in a Guinea Pig Model of Spontaneous Intrauterine Growth Restriction"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-306X","authenticated-orcid":false,"given":"Simran","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-9766","authenticated-orcid":false,"given":"Lanette J.","family":"Friesen\u2010Waldner","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-8358","authenticated-orcid":false,"given":"Timothy R.H.","family":"Regnault","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Western University  London Ontario Canada"},{"name":"Department of Physiology &amp; Pharmacology Western University  London Ontario 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