{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:53Z","timestamp":1790694893034,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Portal vein thrombosis (PVT) is thought to arise from stagnant blood flow, yet conclusive evidence is lacking. Relative residence time (RRT) assessed using 4D Flow MRI may offer insight into portal flow stagnation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the relationship between RRT values and the presence of PVT in cirrhotic participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty\u2010eight participants with liver cirrhosis (27 males, median age 67\u2009years [IQR: 57\u201373]) and 20 healthy control participants (12 males, median age 45\u2009years [IQR: 40\u201354]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T\/4D Flow MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Laboratory (liver and kidney function test results and platelet count) and clinical data (presence of tumors and other imaging findings), and portal hemodynamics derived from 4D Flow MRI (spatiotemporally averaged RRT [RRT\u2010mean], flow velocity, and flow rate) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>We used multivariable logistic regression, adjusted by selected covariates through the Lasso method, to explore whether RRT\u2010mean is an independent risk factor for PVT. The area under the ROC curve (AUC) was also calculated to assess the model's discriminative ability. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 indicated statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The liver cirrhosis group consisted of 16 participants with PVT and 32 without PVT. Higher RRT\u2010mean values (odds ratio [OR] 11.4 [95% CI: 2.19, 118]) and lower platelet count (OR 0.98 per 1000\u2009\u03bcL [95% CI: 0.96, 0.99]) were independent risk factors for PVT. The incorporation of RRT\u2010mean (AUC, 0.77) alongside platelet count (AUC, 0.75) resulted in an AUC of 0.84. When including healthy control participants, RRT\u2010mean had an adjusted OR of 12.4 and the AUC of the combined model (RRT\u2010mean and platelet count) was 0.90.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Prolonged RRT values and low platelet count were significantly associated with the presence of PVT in cirrhotic participants. RRT values derived from 4D Flow MRI may have potential clinical relevance in the management of PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29357","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:35:44Z","timestamp":1710570944000},"page":"2592-2601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of <scp>4D<\/scp> Flow MRI\u2010Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-4782","authenticated-orcid":false,"given":"Ryota","family":"Hyodo","sequence":"first","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-5997","authenticated-orcid":false,"given":"Yasuo","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Center for Advanced Medicine and Clinical Research Department of Advanced Medicine Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Transplantation Surgery Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Transplantation Surgery Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-613X","authenticated-orcid":false,"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jin","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA Inc.  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