{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:41:55Z","timestamp":1789576915417,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is a significant risk factor for osteoarthritis (OA). The most effective treatment for morbid obesity is bariatric surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the effects of potential surgically induced weight loss on knee articular cartilage and OA symptoms of obese patients over a 12\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective longitudinal cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>45 obese patients (38 female, BMI\u2009=\u200942.3\u2009\u00b1\u20096.5\u2009kg\/m<jats:sup>2<\/jats:sup>) who underwent gastric bypass (intervention group), and 46 age\u2010matched conservative\u2010care controls (37 female, BMI\u2009=\u200939.8\u2009\u00b1\u20094.6\u2009kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Multiecho spin echo sequence at 3\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Knee cartilage T2 measurements and WOMAC Indices were measured presurgery and after 12\u2009months. The intervention group was split into successful (\u226520% total weight loss (TWL)) and unsuccessful (&lt;20% TWL) weight loss groups. T2 and WOMAC indices were also measured in controls at baseline and after 12\u2009months. Changes among the three groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Analysis of variance (significance level 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six (58%) intervention patients achieved \u226520% TWL. The &lt;20% TWL group demonstrated significantly more T2 reduction in the deep lateral femur over 12\u2009months compared with the \u226520% TWL group (\u22123.83\u2009\u00b1\u20098.18\u2009msec vs. 2.47\u2009\u00b1\u20096.54\u2009msec, respectively), whereas no significant differences were observed on the medial femoral compartment (<jats:italic>P<\/jats:italic>\u2009=\u20090.385, <jats:italic>P<\/jats:italic>\u2009=\u20090.551, and <jats:italic>P<\/jats:italic>\u2009=\u20090.511 for bulk, superficial and deep regions, respectively). Changes in WOMAC indices over 12\u2009months were significantly greater in the \u226520% TWL group compared with controls. In the &lt;20% TWL group, pain significantly improved over 12\u2009months compared with controls, while stiffness and function changes were not statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.063 and <jats:italic>P<\/jats:italic>\u2009=\u20090.051, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Cartilage matrix, measured by T2, showed improvement on lateral femoral cartilage with &lt;20% TWL compared with \u226520% TWL. Bariatric surgery provided significant improvements in knee symptoms with \u226520% TWL compared with conservative WL. This effect is also seen to some extent with &lt;20% TWL compared with conservative WL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 4<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29369","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:29:29Z","timestamp":1711963769000},"page":"2433-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Bariatric Surgery on Knee Articular Cartilage and Osteoarthritis Symptoms\u2014A 12\u2010Month Follow\u2010Up Using <scp>T2<\/scp> Relaxation Time and <scp>WOMAC<\/scp> Osteoarthritis Index"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-9749","authenticated-orcid":false,"given":"Sami","family":"Lehtovirta","sequence":"first","affiliation":[{"name":"Research Unit of 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