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While the volumetric changes have been explored in many imaging studies, few studies have investigated the vascular degeneration associated with aging in the ChP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the sub\u2010structural characteristics of the ChP, particularly the vascular compartment using high\u2010resolution 7T imaging enhanced with Ferumoxytol, an ultrasmall super\u2010paramagnetic iron oxide, which greatly increase the susceptibility contrast for vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Forty\u2010nine subjects without neurological disorders (age: 21\u201380\u2009years; 42\u2009\u00b1\u200917\u2009years; 20 females).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>7\u2010T with 2D and 3D T2* GRE, 3D MPRAGE T1, 2D TSE T2, and 2D FLAIR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The vascular and stromal compartments of the ChP were segmented using K\u2010means clustering on post\u2010contrast 2D GRE images. Visual and qualitative assessment of ChP vascular characteristics were conducted independently by three observers. Vascular density (Vol<jats:sub>vessel<\/jats:sub>\/Vol<jats:sub>ChP<\/jats:sub> ratio) and susceptibility change (\u0394<jats:italic>\u03c7<\/jats:italic>) induced by Ferumoxytol were analyzed on 3D GRE\u2010derived susceptibility\u2010weighted imaging and quantitative susceptibility mapping, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Independent <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, and Chi\u2010square test were utilized for group comparisons. The relationship between age and ChP's vascular alterations was examined using Pearson's correlation. Intra\u2010class coefficient was calculated for inter\u2010observer agreement. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>2D GRE images demonstrated superior contrast and accurate delineation of ChP substructures (ICC\u2009=\u20090.86). Older subjects exhibited a significantly smaller vascular density (16.5\u2009\u00b1\u20094.34%) and lower \u0394<jats:italic>\u03c7<\/jats:italic> (22.10\u2009\u00b1\u200912.82\u2009ppb) compared to younger subjects (24.85\u2009\u00b1\u20096.84% and 34.64\u2009\u00b1\u200912.69\u2009ppb). Vascular density and mean \u0394<jats:italic>\u03c7<\/jats:italic> within the ChP negatively correlated with age (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.48, and <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Ferumoxytol\u2010enhanced 7T images can demonstrate ChP alterations in elderly with decreased vascular density and expansion of nonvascular compartment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29381","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:50:45Z","timestamp":1712577045000},"page":"2564-2575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vascular Aging in the Choroid Plexus: A <scp>7T<\/scp> Ultrasmall Superparamagnetic Iron Oxide (<scp>USPIO<\/scp>)\u2010<scp>MRI<\/scp> Study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-8675","authenticated-orcid":false,"given":"Zhe","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"},{"name":"Vilcek Institute of Graduate Medical Sciences, NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"},{"name":"Vilcek Institute of Graduate Medical Sciences, NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Muccio","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Masurkar","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Buch","sequence":"additional","affiliation":[{"name":"Department of Neurology Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-5731","authenticated-orcid":false,"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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