{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:36Z","timestamp":1791910776687,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974262"],"award-info":[{"award-number":["81974262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac diffusion\u2010weighted imaging (DWI) using second\u2010order motion\u2010compensated spin echo (M2C) can provide noninvasive in\u2010vivo microstructural assessment, but limited by relatively low signal\u2010to\u2010noise ratio (SNR). Echo\u2010planar imaging (EPI) with compressed sensitivity encoding (EPICS) could address these issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To combine M2C DWI and EPCIS (M2C EPICS DWI), and compare image quality for M2C DWI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ten ex\u2010vivo hearts, 10 healthy volunteers (females, 5 [50%]; mean\u2009\u00b1\u2009SD of age, 25\u2009\u00b1\u20094\u2009years), and 12 patients with diseased hearts (female, 1 [8.3%]; mean\u2009\u00b1\u2009SD of age, 44\u2009\u00b1\u200916\u2009years; including coronary artery heart disease, congenital heart disease, dilated cardiomyopathy, amyloidosis, and myocarditis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, M2C EPICS DWI, and M2C DWI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The apparent SNR (aSNR) and the rating scores were used to evaluate and compared image quality of all three groups. The aSNR was calculated using , and the myocardium was segmented manually. Three observers independently rated subjective image quality using a 5\u2010point Likert scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Bland\u2013Altman analysis and paired <jats:italic>t<\/jats:italic>\u2010tests. The threshold for statistical significance was set at <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy volunteers, the aSNR with a <jats:italic>b<\/jats:italic>\u2010value of 450\u2009s\/mm<jats:sup>2<\/jats:sup> acquired by M2C EPICS DWI was significantly higher than M2C DWI at in\u2010plane resolutions of 3.0\u2009\u00d7\u20093.0, 2.5\u2009\u00d7\u20092.5, and 2.0\u2009\u00d7\u20092.0\u2009mm<jats:sup>2<\/jats:sup>. In patients with diseased hearts, the aSNR ofM2C EPICS DWI was also significantly higher than that for M2C DWI (bias of M2C EPICS\u2010M2C\u2009=\u20091.999, 95% limits of agreement, 0.362 to 3.636; mean\u2009\u00b1\u2009SD, 7.80\u2009\u00b1\u20091.37 vs. 5.80\u2009\u00b1\u20090.81). The ADC values of M2C EPICS was significantly higher than M2C DWI in in\u2010vivo hearts. Over 80% of the images with rating scores for M2C EPICS DWI were higher than M2C DWI in in\u2010vivo hearts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Cardiac imaging by M2C EPICS DWI may demonstrate better overall image quality and higher aSNR than M2C DWI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29383","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:38:33Z","timestamp":1712576313000},"page":"305-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Second\u2010Order Motion\u2010Compensated Echo\u2010Planar Cardiac Diffusion\u2010Weighted <scp>MRI<\/scp>: Usefulness of Compressed Sensitivity Encoding"],"prefix":"10.1002","volume":"61","author":[{"given":"Rui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhou","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of MSC Clinical &amp; 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