{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:05:39Z","timestamp":1785229539645,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515120089"],"award-info":[{"award-number":["2021B1515120089"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220115"],"award-info":[{"award-number":["2022A1515220115"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>White matter hyperintensity (WMH) burden may lead to poor clinical outcomes after endovascular thrombectomy (EVT). But the relationship between WMH burden and cerebral edema (CED) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the association between WMH burden and CED and functional outcome in patients treated with EVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subject<\/jats:title><jats:p>344 patients with acute anterior circulation large\u2010vessel occlusion stroke who received EVT at two comprehensive stroke centers. Mean age was 62.6\u2009\u00b1\u200911.6\u2009years and 100 patients (29.1%) were female.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T, including diffusion\u2010weighted imaging and fluid\u2010attenuated inversion recovery (<jats:styled-content style=\"fixed-case\">FLAIR<\/jats:styled-content>) images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The severity of WMH was evaluated using the Fazekas scale on a FLAIR sequence before EVT. The severity of CED was assessed using CED score (three for malignant cerebral edema [MCE]) and net water uptake (NWU)\/time on post\u2010EVT cranial CT. The impact of WMH burden on MCE, NWU\/time, and 3\u2010month poor outcome (modified Rankin scale &gt;2) after EVT were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Pearson's chi\u2010squared test, Fisher exact test, 2\u2010tailed <jats:italic>t<\/jats:italic> test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, multivariable logistic regression, multivariate regression analysis, Sobel test. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WMH burden was not significantly associated with MCE and parenchymal hemorrhage (PH) in the whole population (<jats:italic>P<\/jats:italic>\u2009=\u20090.072; <jats:italic>P<\/jats:italic>\u2009=\u20090.714). WMH burden was significantly associated with an increased risk of MCE (OR, 1.550; 95% CI, 1.128\u20132.129), higher NWU\/time\u00a0(Coefficient, 0.132; 95% CI, 0.012\u20130.240), and increased risk of 3\u2010month poor outcome (OR, 1.434; 95% CI, 1.110\u20131.853) in the subset of patients without PH. Moreover, the connection between WMH burden and poor outcome was partly mediated by CED in patients without PH (regression coefficient changed by 29.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>WMH burden is associated with CED, especially MCE, and poor outcome in acute ischemic stroke patients treated with EVT. The association between WMH burden and poor outcome may partly be attributed to postoperative CED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29423","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:04:58Z","timestamp":1715259898000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["White Matter Hyperintensity is Associated with Malignant Cerebral Edema in Ischemic Stroke Treated with Thrombectomy"],"prefix":"10.1002","volume":"61","author":[{"given":"Lihua","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province 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