{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:16:49Z","timestamp":1775841409041,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971581"],"award-info":[{"award-number":["81971581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271517"],"award-info":[{"award-number":["82271517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neonates with immature auditory function (eg, weak\/absent middle ear muscle reflex) could conceivably be vulnerable to noise\u2010induced hearing loss; however, it is unclear if neonates show evidence of hearing loss following MRI acoustic noise exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the auditory effects of MRI acoustic noise in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Two independent cohorts of neonates (N\u2009=\u200919 and N\u2009=\u200918; mean gestational\u2010age, 38.75\u2009\u00b1\u20092.18 and 39.01\u2009\u00b1\u20091.83\u2009weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T1\u2010weighted three\u2010dimensional gradient\u2010echo sequence, T2\u2010weighted fast spin\u2010echo sequence, single\u2010shot echo\u2010planar imaging\u2010based diffusion\u2010tensor imaging, single\u2010shot echo\u2010planar imaging\u2010based diffusion\u2010kurtosis imaging and T2\u2010weighted fluid\u2010attenuated inversion recovery sequence at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>All neonates wore ear protection during scan protocols lasted ~40\u2009minutes. Equivalent sound pressure levels (SPLs) were measured for both cohorts. In cohort1, left\u2010 and right\u2010ear auditory brainstem response (ABR) was measured before (baseline) and after (follow\u2010up) MRI, included assessment of ABR threshold, wave I, III and V latencies and interpeak interval to determine the functional status of auditory nerve and brainstem. In cohort2, baseline and follow\u2010up left\u2010 and right\u2010ear distortion product otoacoustic emission (DPOAE) amplitudes were assessed at 1.2 to 7.0\u2009kHz to determine cochlear function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Test<\/jats:title><jats:p>Wilcoxon signed\u2010rank or paired <jats:italic>t<\/jats:italic>\u2010tests with Bonferroni's correction were used to compare the differences between baseline and follow\u2010up ABR and DPOAE measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Equivalent SPLs ranged from 103.5 to 113.6\u2009dBA. No significant differences between baseline and follow\u2010up were detected in left\u2010 or right\u2010ear ABR measures (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.999, Bonferroni corrected) in cohort1, or in DPOAE levels at 1.2 to 7.0\u2009kHz in cohort2 (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.999 Bonferroni corrected except for left\u2010ear levels at 3.5 and 7.0\u2009kHz with corrected <jats:italic>P<\/jats:italic>\u2009=\u20090.138 and <jats:italic>P<\/jats:italic>\u2009=\u20090.533).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>A single 40\u2010minute 3\u2010T MRI with equivalent SPLs of 103.5\u2013113.6\u2009dBA did not result in significant transient disruption of auditory function, as measured by ABR and DPOAE, in neonates with adequate hearing protection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29450","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T01:05:44Z","timestamp":1716426344000},"page":"2332-2340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Auditory Effects of Acoustic Noise From <scp>3\u2010T<\/scp> Brain <scp>MRI<\/scp> in Neonates With Hearing Protection"],"prefix":"10.1002","volume":"60","author":[{"given":"Chao","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Xi'an Jiaotong University  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