{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T08:51:31Z","timestamp":1764492691374,"version":"3.32.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071989","82071989;82371911","82372075"],"award-info":[{"award-number":["82071989","82071989;82371911","82372075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ki\u201067 and human epidermal growth factor receptor 2 (HER2) are known oncogenes involved in bladder cancer (BCa) patient risk stratification. Preoperative assessment of their expression level can assist in clinical treatment decision\u2010making. Recently, amide proton transfer\u2010weighted (APTw) MRI has shown promising potential in the diagnosis of several malignancies. However, few studies reported the value of APTw imaging in evaluating Ki\u201067 and HER2 status of BCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the feasibility of APTw MRI in assessing the aggressive and proliferative potential regarding the expression levels of Ki\u201067 and HER2 in BCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>114 patients (mean age, 64.78\u2009\u00b1\u200911.93 [SD] years; 97 men) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>APTw MRI acquired by a three\u2010dimensional fast\u2010spin\u2010echo sequence at 3.0\u2009T MRI system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Patient pathologic findings, included histologic grade and the expression status of Ki\u201067 and HER2, were reviewed by one uropathologist. The APTw values of BCa were independently measured by two radiologists and were compared between high\u2212\/low\u2010tumor grade group, high\u2212\/low\u2010Ki\u201067 expression group, and high\u2212\/low\u2010HER2 expression group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The interclass correlation coefficient, independent sample <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney U test, Spearman's rank correlation, and receiver operating characteristic curve (ROC) analysis were used. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher APTw values were found in high\u2010grade BCa patients (7.72% vs. 4.29%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), high\u2010Ki\u201067 expression BCa patients (8.40% vs. 3.25%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and HER2 positive BCa patients (8.24% vs. 5.40%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). APTw values were positively correlated with Ki\u201067 (<jats:italic>r<\/jats:italic>\u2009=\u20090.769) and HER2 (<jats:italic>r<\/jats:italic>\u2009=\u20090. 356) expression status. The area under the ROC curve of the APTw values for detecting Ki\u201067 and HER2 expression status were 0.883 (95% CI: 0.790\u20130.945) and 0.713 (95% CI: 0.592\u20130.816), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusions<\/jats:title><jats:p>APTw MRI is a potential method to assess the biological and proliferation potential of BCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29464","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T08:19:06Z","timestamp":1717229946000},"page":"704-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amide Proton Transfer\u2010Weighted Imaging in Assessing the Aggressive and Proliferative Potential of Bladder Cancer"],"prefix":"10.1002","volume":"61","author":[{"given":"Lingmin","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong 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