{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:02:23Z","timestamp":1782990143422,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171897"],"award-info":[{"award-number":["82171897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371923"],"award-info":[{"award-number":["82371923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23Y11907400"],"award-info":[{"award-number":["23Y11907400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240152"],"award-info":[{"award-number":["202240152"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Regional lymph node metastasis (LNM) assessment is crucial for predicting intrahepatic cholangiocarcinoma (iCCA) prognosis. However, imaging assessment has limitations for identifying LNM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the association between MRI radiomics features, regional LNM status, and prognosis in iCCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Two hundred ninety\u2010six patients (male\u2009=\u2009197) with surgically confirmed iCCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5\u2009T and 3.0\u2009T. DWI, T2WI, and contrast\u2010enhanced T1WI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Clinical information, radiologic, and MRI\u2010based radiomics features associated with LNM status were collected to establish models. Performance of MRI, PET\/CT, and the combined LNM models were compared in training (N\u2009=\u2009207) and test (N\u2009=\u200989) datasets. Overall survival (OS) was compared based on LNM status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The independent features were selected by 5\u2010fold cross\u2010validation. The performance of MRI, PET\/CT, and the models was evaluated using the area under receiver operating characteristic curve (AUC). Univariable and multivariable Cox regression were used to identify independent variables for OS. Kaplan\u2013Meier curves were compared with the log\u2010rank test between LNM positive and negative groups. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intrahepatic duct dilatation, enhancement pattern, and CA19\u20109 were independent clinicoradiologic features. The radiomics model was constructed by the independent radiomics features extracted from T2WI and delay phase T1WI. The combined LNM model showed AUC of 0.888, 0.884, and 0.811 in training, validation, and test cohorts with a positive net benefit. PET\/CT exhibited similar sensitivity to the combined LNM model (0.750 vs. 0.733, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.999) while the combined LNM model showed higher specificity (0.703 vs. 0.630, <jats:italic>P<\/jats:italic>\u2009=\u20090.039) in the test cohort. High risk of regional LNM was significantly associated with worse OS (median: 24\u2009months) than low risk (median: 30\u2009months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusions<\/jats:title><jats:p>The combined LNM model has the strongest correlation with LNM status for mass\u2010forming iCCA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29477","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:50:32Z","timestamp":1719312632000},"page":"997-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association Between <scp>MRI<\/scp>\u2010Based Radiomics Features and Regional Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma and Its Clinical Outcome"],"prefix":"10.1002","volume":"61","author":[{"given":"Xianling","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengyun","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Intelligence Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Central Research Institute United Imaging Healthcare  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Intelligence Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-3623","authenticated-orcid":false,"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging  Shanghai China"},{"name":"Department of Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21759"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0446"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.157"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0527-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2019.06.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318176c4d3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6519"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.04.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2018.07.03"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003788"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-3899-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.01.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10827"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.9084"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-023-03991-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0791-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02458-x"},{"key":"e_1_2_8_21_1","first-page":"11","article-title":"Comparison of conventional imaging and 18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography in the diagnostic accuracy of staging in patients with intrahepatic cholangiocarcinoma","volume":"12","author":"Nishioka E","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182867b99"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.01.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1005924"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.11.036"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12028-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06142-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34149"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i42.9279"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10477-7"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5920"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-21-25"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181494"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10025-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.01.024"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5898-9"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T16:38:11Z","timestamp":1736267891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jmri.29477"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29477","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}