{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:04:34Z","timestamp":1753740274161,"version":"3.32.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2017\u2010I2M\u20101\u2010005"],"award-info":[{"award-number":["2017\u2010I2M\u20101\u2010005"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1308700"],"award-info":[{"award-number":["2017YFC1308700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preoperative differentiation of the types of mediastinal tumors is essential. Magnetic resonance (MR) elastography potentially provides a noninvasive method to assess the classification of mediastinal tumor subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the use of MR elastography in anterior mediastinal masses and to characterize the mechanical properties of tumors of different subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>189 patients with anterior mediastinal tumors (AMTs) confirmed by histopathology (62 thymomas, 53 thymic carcinomas, 57 lymphomas, and 17 germ cell tumors).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A gradient echo\u2010based 2D MR elastography sequence and a diffusion\u2010weighted imaging (DWI) sequence at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Stiffness and apparent diffusion coefficients (ADC) were measured in AMTs using MR elastography\u2010derived elastograms and DWI\u2010derived ADC maps, respectively. The aim of this study is to identify whether MR elastography can differentiate between the histological subtypes of ATMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of variance (ANOVA), two\u2010way ANOVA, Pearson's linear correlation coefficient (<jats:italic>r<\/jats:italic>), receiver operating characteristic (ROC) curve analysis; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lymphomas had significantly lower stiffness than other AMTs (4.0\u2009\u00b1\u20090.63\u2009kPa vs. 4.8\u2009\u00b1\u20091.39\u2009kPa). The mean stiffness of thymic carcinomas was significantly higher than that of other AMTs (5.6\u2009\u00b1\u20091.41\u2009kPa vs. 4.2\u2009\u00b1\u20090.94\u2009kPa). Using a cutoff value of 5.0\u2009kPa, ROC analysis showed that lymphomas could be differentiated from other AMTs with an accuracy of 59%, sensitivity of 97%, and specificity of 38%. Using a cutoff value of 5.1\u2009kPa, thymic carcinomas could be differentiated from other AMTs with an accuracy of 84%, sensitivity of 67%, and specificity of 90%. However, there was an overlap in the stiffness values of individual thymomas (4.2\u2009\u00b1\u20090.71; 3.9\u20134.5), thymic carcinomas (5.6\u2009\u00b1\u20091.41; 5.0\u20136.1), lymphomas (4.0\u2009\u00b1\u20090.63; 3.8\u20134.2), and germ cell tumors (4.5\u2009\u00b1\u20091.79; 3.3\u20135.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MR elastography\u2010derived stiffness may be used to evaluate AMTs of various histologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29481","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T09:29:06Z","timestamp":1718011746000},"page":"841-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic Resonance Elastography of 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