{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:04Z","timestamp":1790352544682,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac MRI feature tracking (FT) allows objective assessment of segmental left ventricular (LV) function following a myocardial infarction (MI), but its utilization in sheep, where interventions can be tested, is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To apply and validate FT in a sheep model of MI and describe post\u2010MI LV remodeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Animal model, longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Eighteen lambs (6\u2009months, male, n\u2009=\u200914; female, n\u2009=\u20094; 25.2\u2009\u00b1\u20094.5\u2009kg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Two\u2010dimensional balanced steady\u2010state free precession (bSSFP) and 3D inversion recovery fast low angle shot (IR\u2010FLASH) sequences at 3\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Seven lambs underwent test\u2013retest imaging to assess FT interstudy reproducibility. MI was induced in the remaining 11 by coronary ligation with MRI being undertaken before and 15\u2009days post\u2010MI. Injury size was measured by late gadolinium enhancement (LGE) and LV volumes, LV mass, ejection fraction (LVEF), and wall thickness (LVWT) were measured, with FT measures of global and segmental radial, circumferential, and longitudinal strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Sampling variability, inter\u2010study, intra and interobserver reproducibility were assessed using Pearson's correlation, Bland\u2013Altman analyses, and intra\u2010class correlation coefficients (ICC). Diagnostic performance of segmental strain to predict LGE was assessed using receiver operating characteristic curve analysis. Significant differences were considered <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010study reproducibility of FT was overall good to excellent, with global strain being more reproducible than segmental strain (ICC\u2009=\u20090.89\u20130.98 vs. 0.77\u20130.96). MI (4.0\u2009\u00b1\u20093.7% LV mass) led to LV remodeling, as evident by significantly increased LV volumes and LV mass, and significantly decreased LVWT in injured regions, while LVEF was preserved (54.9\u2009\u00b1\u20096.9% vs. 55.6\u2009\u00b1\u20095.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.778). Segmental circumferential strain (CS) correlated most strongly with LGE. Basal and mid\u2010 CS increased significantly, while apical CS significantly decreased post\u2010MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>FT is reproducible and compensation by hyperkinetic remote myocardium may manifest as overall preserved global LV function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>N\/A<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29496","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T11:41:32Z","timestamp":1719574892000},"page":"1323-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Post\u2010Myocardial Infarction Remodeling and Hyperkinetic Remote Myocardium in Sheep Measured by Cardiac <scp>MRI<\/scp> Feature Tracking"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-0192","authenticated-orcid":false,"given":"Steven K.S.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R.T.","family":"Darby","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences University of South Australia  Adelaide South Australia 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