{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:34:19Z","timestamp":1791005659843,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871435"],"award-info":[{"award-number":["81871435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2301900"],"award-info":[{"award-number":["2021YFC2301900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019PT320019"],"award-info":[{"award-number":["2019PT320019"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the advent of combination antiretroviral therapy, people living with human immunodeficiency virus (PLWH) are at an increased risk for cardiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the presence and extent of diastolic atrial and left ventricular dysfunction in PLWH using cardiac MRI in correlation with clinical markers of disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 163 participants comprising 101 HIV\u2010infected individuals (age: 52\u2009years [42\u201362\u2009years]; 92% male) and 62 age\u2010 and sex\u2010matched healthy volunteers (age: 51\u2009years [30\u201372\u2009years]; 85% male).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T, cardiac <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> including balanced steady\u2010state free precession (<jats:styled-content style=\"fixed-case\">SSFP<\/jats:styled-content>) for the short\u2010axis, two\u2010, three\u2010, and four\u2010chamber views were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Assessment of cardiac function and strain analysis were accomplished by CVI42 software. Blood samples for CD4<jats:sup>+<\/jats:sup> T cells and cardiac risk factors were also collected before MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Independent <jats:italic>t<\/jats:italic> tests, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, Pearson's correlation analysis, and multivariate linear analyses (significance level: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PLWH had a significantly larger left atrial volume maximum index (LAVImax: 32.6\u2009\u00b1\u20098.7 vs. 28.7\u2009\u00b1\u20098.1\u2009mL\/m<jats:sup>2<\/jats:sup>), minimum (LAVImin: 14.8\u2009\u00b1\u20095.5 vs. 11.5\u2009\u00b1\u20095.4\u2009mL\/m<jats:sup>2<\/jats:sup>,), and prior to atrial contraction (LAVIpre\u2010a: 23.4\u2009\u00b1\u20096.7 vs. 19.7\u2009\u00b1\u20097.2\u2009mL\/m<jats:sup>2<\/jats:sup>) as compared to healthy volunteers. The LA reservoir (LAtEF: 55.0\u2009\u00b1\u200910.2 vs. 61.4\u2009\u00b1\u200910.4; Sls: 29.0\u2009\u00b1\u20098.1 vs. 33.8\u2009\u00b1\u200911.8), conduit (LApEF: 28.4\u2009\u00b1\u20098.2 vs. 32.3\u2009\u00b1\u200911.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.01; Sle: 16.3\u2009\u00b1\u20096.5 vs. 18.9\u2009\u00b1\u20098.2), and booster pump function (LAaEF: 37.4\u2009\u00b1\u200912.4 vs. 42.7\u2009\u00b1\u200913.1, <jats:italic>P<\/jats:italic>\u2009=\u20090.01, Sla: 12.7\u2009\u00b1\u20095.1 vs. 14.9\u2009\u00b1\u20095.7) were all significant impaired in PLWH. Global circumferential left ventricular diastolic strain rate (LVGCS\u2010d) was significantly lower in the HIV patients. Multivariate analysis results showed that Nadir CD4<jats:sup>+<\/jats:sup> T cells had a significant adverse association with LVGCS\u2010d (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LA structure abnormalities and LV diastolic dysfunction were manifested in PLWH, with Nadir CD4+ T cell counts potentially serving as a risk factor for early cardiac diastolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29503","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T19:11:24Z","timestamp":1720552284000},"page":"1286-1298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MRI<\/scp> Assessment of Diastolic Dysfunction in People Living With the Human Immunodeficiency Virus: Correlation With Markers of Disease Activity"],"prefix":"10.1002","volume":"61","author":[{"given":"Yue","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"},{"name":"NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology of Liaoning Province The First Hospital of China Medical University  Shenyang China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"},{"name":"NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology of Liaoning Province The First Hospital of China Medical University  Shenyang China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"},{"name":"NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology of Liaoning Province The First Hospital of China Medical University  Shenyang China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"},{"name":"NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology of Liaoning Province The First Hospital of China Medical University  Shenyang China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-6996","authenticated-orcid":false,"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01741-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.057443"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs471"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004574"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.073"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61809-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1310\/hct1103-156"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab221"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131971"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005163"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/529523"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/506366"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab245"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.01.042"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.02.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004430"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab037"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004299"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007512"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019709"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004091"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.756162"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001719"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv274"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00714.2005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/374786"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20032201"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2013.12.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.854943"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-022-00901-0"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T11:31:50Z","timestamp":1738927910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jmri.29503"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29503","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}