{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:23:50Z","timestamp":1769606630897,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP200101845"],"award-info":[{"award-number":["DP200101845"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>How the biophysics of electrical conductivity measures relate to brain activity is poorly understood. The sedative, ethanol, reduces metabolic activity but its impact on brain electrical conductivity is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether ethanol reduces brain electrical tissue conductivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Fifty\u2010two healthy volunteers (aged 18\u201337\u2009years, 22 females, 30 males).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T, T1\u2010weighted, multi\u2010shot, turbo\u2010field echo (TFE); 3D balanced fast\u2010field echo (bFFE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Brain gray and white matter tissue conductivity measured with phase\u2010based magnetic resonance electrical properties tomography (MREPT) compared before and 20\u2009minutes after ethanol consumption (0.7\u2009g\/kg body weight). Differential conductivity whole brain maps were generated for three subgroups: those with strong (\u2009&gt;\u20090.1\u2009S\/m; N\u2009=\u200933), weak (0.02\u2009S\/m\u2009\u2264\u2009\u2009\u2264\u20090.1\u2009S\/m; N\u2009=\u20099) conductivity decrease, and no significant response (\u2009&lt;\u20090.02\u2009S\/m, N\u2009=\u200910). Maps were compared in the strong response group where breath alcohol rose between scans, vs. those where it fell.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Average breath alcohol levels were compared to the differential conductivity maps using linear regression. T\u2010maps were generated (threshold <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; minimum cluster 48\u2009mm<jats:sup>3<\/jats:sup>). Differential conductivity maps were compared with ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whole\u2010group analysis showed decreased conductivity that did not survive statistical thresholding. Strong responders (N\u2009=\u200933) showed a consistent pattern of significantly decreased conductivity (\u2009&gt;\u20090.1\u2009S\/m) in frontal\/occipital and cerebellar white matter. The weak response group (N\u2009=\u20099) showed a similar pattern of conductivity decrease (0.02\u2009S\/m\u2009\u2264\u2009\u2009\u2264\u20090.1\u2009S\/m). There was no significant relationship with breath alcohol levels, alcohol use, age, ethnicity, or sex. The strong responders' regional response was different between ascending (N\u2009=\u200912) or descending (N\u2009=\u200920) alcohol during the scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Ethanol reduces brain tissue conductivity in a participant\u2010dependent and spatially dependent fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29548","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T14:02:03Z","timestamp":1722952923000},"page":"1181-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Ethanol on Brain Electrical Tissue Conductivity in Social Drinkers"],"prefix":"10.1002","volume":"61","author":[{"given":"Jun","family":"Cao","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain K.","family":"Ball","sequence":"additional","affiliation":[{"name":"Philips Australia &amp; New Zealand  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-7703","authenticated-orcid":false,"given":"Elizabeth","family":"Summerell","sequence":"additional","affiliation":[{"name":"School of Psychology, The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Humburg","sequence":"additional","affiliation":[{"name":"Mark Wainwright Analytical Centre, Stats Central, The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-4280","authenticated-orcid":false,"given":"Tom","family":"Denson","sequence":"additional","affiliation":[{"name":"School of Psychology, The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-8084","authenticated-orcid":false,"given":"Caroline D.","family":"Rae","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Sydney New South Wales Australia"},{"name":"School of Psychology, The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12634"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0895-9_10"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90065-E"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-7552(77)90025-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.07.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3729"},{"key":"e_1_2_7_10_1","article-title":"Electrical properties tomography based functional magnetic resonance imaging (EPT\u2010fMRI)","volume":"27","author":"Helle M","year":"2019","journal-title":"Proc Int Soc Magn Res Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-023-01248-1"},{"key":"e_1_2_7_13_1","unstructured":"KatscherU DjamshidiK VoigtT et al.Estimation of breast tumor conductivity using parabolic phase fitting. 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