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The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the most consistent regions of resting\u2010state functional brain activity abnormality in patients with TLE through a quantitative meta\u2010analysis of published neuroimaging data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Exactly 1474 TLE patients (716 males and 758 females) from 31 studies on resting\u2010state functional brain activity were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Studies utilizing 1.5\u2009T or 3\u2009T MR scanners were included for meta\u2010analysis. Resting\u2010state functional MRI using gradient echo\u2010planar imaging, T1\u2010weighted imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases were searched to identify studies investigating amplitude of low\u2010frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) at the whole\u2010brain level between patients with TLE and healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Seed\u2010based <jats:italic>d<\/jats:italic> Mapping with Permutation of Subject Images, standard randomization tests and meta\u2010regression analysis were used. Results were significant if <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 with family\u2010wise error corrected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with TLE displayed resting\u2010state functional brain activity which was a significant increase in the right hippocampus, and significant decrease in the right angular gurus and right precuneus. Additionally, the meta\u2010regression analysis demonstrated that age (<jats:italic>P<\/jats:italic>\u2009=\u20090.231), sex distribution (<jats:italic>P<\/jats:italic>\u2009=\u20090.376), and illness duration (<jats:italic>P<\/jats:italic>\u2009=\u20090.184), did not show significant associations with resting state functional brain activity in patients with TLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Common alteration patterns of spontaneous brain activity were identified in the right hippocampus and default\u2010model network regions in patients with TLE. These findings may contribute to understanding of the underlying mechanism for potentially effective intervention of TLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29568","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T09:04:00Z","timestamp":1725095040000},"page":"1782-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta\u2010Analysis of 1474 Patients"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-0548","authenticated-orcid":false,"given":"Shu","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Medical Imaging The Affiliated Guangdong Second 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