{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:45:57Z","timestamp":1769010357181,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Middle cerebral artery (MCA) plaques are a leading cause of ischemic stroke (IS). Plaque inflammation is crucial for plaque stability and urgently needs quantitative detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the utility of Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA)\u2010Dixon\u2010Time\u2010resolved angiography With Interleaved Stochastic Trajectories (TWIST) (CDT) dynamic contrast\u2010enhanced MRI (DCE\u2010MRI) for evaluating MCA culprit plaque inflammation changes over stroke time and with diabetes mellitus (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ninety\u2010four patients (51.6\u2009\u00b1\u200912.23\u2009years, 32 females, 23 DM) with acute IS (AIS; N\u2009=\u200943) and non\u2010acute IS (non\u2010AIS; 14\u2009days\u2009&lt;\u2009stroke time\u2009\u2264\u20093\u2009months; N\u2009=\u200951).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, CDT DCE\u2010MRI and three\u2010dimensional (3D) Sampling Perfection with Application optimized Contrast using different flip angle Evolution (3D\u2010SPACE) T1\u2010weighted imaging (T1WI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Stroke time (from initial IS symptoms to MRI) and DM were registered. For 94 MCA culprit plaques, K<jats:sup>trans<\/jats:sup> from CDT DCE\u2010MRI and enhancement ratio (ER) from 3D\u2010SPACE T1WI were compared between groups with and without AIS and DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Shapiro\u2013Wilk test, Bland\u2013Altman analysis, Passing and Bablok test, independent <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, Chi\u2010squared test, Fisher's exact test, receiver operating characteristics (ROC) with the area under the curve (AUC), DeLong's test, and Spearman rank correlation test with the <jats:italic>P<\/jats:italic>\u2010value significance level of 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>K<jats:sup>trans<\/jats:sup> and ER of MCA culprit plaques were significantly higher in AIS than non\u2010AIS patients (K<jats:sup>trans<\/jats:sup>\u2009=\u20090.098\u2009s<jats:sup>\u22121<\/jats:sup> vs. 0.037\u2009s<jats:sup>\u22121<\/jats:sup>; ER\u2009=\u20090.86 vs. 0.55). K<jats:sup>trans<\/jats:sup> showed better AUC for distinguishing AIS from non\u2010AIS patients (0.87 vs. 0.75) and stronger negative correlation with stroke time than ER (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.60 vs. \u22120.34). DM patients had significantly higher K<jats:sup>trans<\/jats:sup> and ER than non\u2010DM patients in IS and AIS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Imaging by CDT DCE\u2010MRI may allow to quantitatively evaluate MCA culprit plaques over stroke time and DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29576","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:50:46Z","timestamp":1726051846000},"page":"2011-2020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Middle Cerebral Artery Culprit Plaque Inflammation in Ischemic Stroke Using <scp>CAIPIRINHA<\/scp>\u2010Dixon\u2010<scp>TWIST<\/scp> Dynamic Contrast\u2010Enhanced Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-2834","authenticated-orcid":false,"given":"Junxia","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Chaoyang Hospital, Capital Medical University  Beijing China"},{"name":"Department of Magnetic Resonance The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuncai","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-9674","authenticated-orcid":false,"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance The First Affiliated Hospital of Zhengzhou University  Zhengzhou 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