{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:59:27Z","timestamp":1784246367821,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK116963"],"award-info":[{"award-number":["R01DK116963"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ductal features alone may not offer high diagnostic sensitivity or most accurate disease severity of chronic pancreatitis (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Diagnose CP based on multiparametric MRI and MRCP features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Between February 2019 and May 2021, 46 control (23 males, 49.3\u2009\u00b1\u200914.1\u2009years), 45 suspected (20 males, 48.7\u2009\u00b1\u200912.5\u2009years), and 46 definite (20 males, 53.7\u2009\u00b1\u200914.6\u2009years) CP patients were enrolled at seven hospitals enrolled in the MINIMAP study. CP classification was based on imaging findings and clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength and Sequences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">1.5\u2009T<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">T<jats:sub>1<\/jats:sub><\/jats:styled-content>\u2010weighted (<jats:styled-content style=\"fixed-case\">T<jats:sub>1<\/jats:sub>W<\/jats:styled-content>) spoiled gradient echo, <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content> map with variable flip angle, dual\u2010echo Dixon, secretin\u2010enhanced <jats:styled-content style=\"fixed-case\">MRCP<\/jats:styled-content> before and after secretin infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Dual\u2010echo fat fraction (FF), T<jats:sub>1<\/jats:sub> relaxation time, extracellular volume (ECV), T<jats:sub>1<\/jats:sub> signal intensity ratio of the pancreas to the spleen (T<jats:sub>1<\/jats:sub> score), arterial\u2010to\u2010venous enhancement ratio (AVR), pancreatic tail diameter (PTD), pancreas volume, late gadolinium enhancement, pancreatic ductal elasticity (PDE), and duodenal filling grade of secretin\u2010enhanced MRCP were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Logistic regression analysis generated CP\u2010MRI and secretin\u2010enhanced CP\u2010SMRI scores. Receiver operating characteristics analysis was used to differentiate definite CP from control. Interobserver agreement was assessed using Lin's concordance correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to control, definite CP cohort showed significantly higher dual\u2010echo FF (7% vs. 11%), lower AVR (1.35 vs. 0.85), smaller PTD (2.5\u2009cm vs. 1.95\u2009cm), higher ECV (28% vs. 38%), and higher incidence of PDE loss (6.5% vs. 50%). With the cut\u2010off of &gt;2.5 CP\u2010MRI score (dual\u2010echo FF, AVR, and PTD) and CP\u2010SMRI score (dual\u2010echo FF, AVR, PTD, and PDE) had cross\u2010validated area under the curves of 0.84 (sensitivity 87%, specificity 68%) and 0.86 (sensitivity 89%, specificity 67%), respectively. Interobserver agreement for both CP\u2010MRI and CP\u2010SMRI scores was 0.74.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CP\u2010MRI and CP\u2010SMRI scores yielded acceptable performance and interobserver agreement for the diagnosis of CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29594","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T13:51:11Z","timestamp":1725371471000},"page":"2183-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multiparametric <scp>MRI<\/scp> Scoring System of the Pancreas for the Diagnosis of Chronic Pancreatitis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-8741","authenticated-orcid":false,"given":"Temel","family":"Tirkes","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Yadav","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwin L.","family":"Conwell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kentucky College of Medicine  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuandong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Dasyam","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Gowdra","family":"Halappa","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashish","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana 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