{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:04:53Z","timestamp":1790813093892,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671646"],"award-info":[{"award-number":["81671646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071911"],"award-info":[{"award-number":["82071911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pathophysiological mechanisms underlying cognitive impairment in end\u2010stage renal disease (ESRD) remain unclear, with limited studies on the temporal variability of neural activity and its coupling with regional perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess neural activity and neurovascular coupling (NVC) in ESRD patients, evaluate the classification performance of these abnormalities, and explore their relationships with cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Exactly 33 <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> patients and 35 age, sex, and education matched healthy controls (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>The 3.0T\/<jats:styled-content style=\"fixed-case\">3D<\/jats:styled-content> pseudo\u2010continuous arterial spin labeling, resting\u2010state functional <jats:styled-content style=\"fixed-case\">MRI,<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">3D<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content> weighted structural imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Dynamic (dfALFF) and static (sfALFF) fractional amplitude of low\u2010frequency fluctuations and cerebral blood flow (CBF) were assessed. CBF\u2010fALFF correlation coefficients and CBF\/fALFF ratio were determined for ESRD patients and HCs. Their ability to distinguish ESRD patients from HCs was evaluated, alongside assessment of cerebral small vessel disease (CSVD) MRI features. All participants underwent blood biochemical and neuropsychological tests to evaluate cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Chi\u2010squared test, two\u2010sample <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests, covariance analysis, partial correlation analysis, family\u2010wise error, false discovery rate, Bonferroni correction, area under the receiver operating characteristic curve (AUC) and multivariate pattern analysis. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 denoted statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ESRD patients exhibited higher dfALFF in triangular part of left inferior frontal gyrus (IFGtriang) and left middle temporal gyrus, lower CBF\/dfALFF ratio in multiple brain regions, and decreased CBF\/sfALFF ratio in bilateral superior temporal gyrus (STG). Compared with CBF\/sfALFF ratio, dfALFF, and sfALFF, CBF\/dfALFF ratio (AUC\u2009=\u20090.916) achieved the most powerful classification performance in distinguishing ESRD patients from HCs. In ESRD patients, decreased CBF\/fALFF ratio correlated with more severe renal impairment, increased CSVD burden, and cognitive decline (0.4\u2009&lt;\u2009|<jats:italic>r<\/jats:italic>|\u2009&lt;\u20090.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>ESRD patients exhibited abnormal dynamic brain activity and impaired NVC, with dynamic features demonstrating superior discriminative capacity and CBF\/dfALFF ratio showing powerful classification performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29597","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T11:00:39Z","timestamp":1725447639000},"page":"1831-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Disturbed Dynamic Brain Activity and Neurovascular Coupling in End\u2010Stage Renal Disease Assessed With <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-377X","authenticated-orcid":false,"given":"Yuhan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiology Zhongshan Hospital Affiliated to Dalian University  Dalian China"},{"name":"Department of Radiology The First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-7649","authenticated-orcid":false,"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated 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