{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:26:49Z","timestamp":1784921209163,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,4]]},"abstract":"Background<\/jats:title>Intravenous Ferumoxtran\u201010 belongs to ultra\u2010small superparamagnetic iron oxide particles and can be used for magnetic resonance neurography (MRN) as an alternative to other imaging methods which use contrast agents.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To examine the impact of intravenous Ferumoxtran\u201010 on vascular suppression and compare image quality to gadolinium (Gd)\u2010enhanced image acquisition in MRN of lumbosacral plexus (LS).<\/jats:p><\/jats:sec>Study Type<\/jats:title>Prospective.<\/jats:p><\/jats:sec>Population\/Subjects<\/jats:title>17 patients with Ferumoxtran\u201010\u2010enhanced MRN, and 20 patients with Gd\u2010enhanced MRN.<\/jats:p><\/jats:sec>Fieldstrength\/Sequence<\/jats:title>3T\/3D STIR sequence.<\/jats:p><\/jats:sec>Assessment<\/jats:title>Image quality, nerve visibility and vascular suppression were evaluated by 3 readers using a 5\u2010point Likert scale.<\/jats:p><\/jats:sec>Statistical Tests<\/jats:title>Inter\u2010reader agreement (IRA) was calculated using intraclass coefficients (ICC). Quantitative analysis of image quality was performed by signal\u2010to\u2010noise ratio (SNR) and contrast\u2010to\u2010noise ratio (CNR) measurements and compared using Student's t\u2010testing.<\/jats:p><\/jats:sec>Results<\/jats:title>Image quality, nerve visibility and vascular suppression were significantly higher for Ferumoxtran\u201010\u2010enhanced MRN compared to Gd\u2010enhanced MRN sequences (p<\/jats:italic>\u2009<\u20090.05). IRA for image quality of nerves was good in Gd\u2010enhanced and Ferumoxtran\u201010 MRN with ICC values of 0.76 and 0.89, respectively. IRA for nerve visibility was good in Gd\u2010 and Ferumoxtran\u201010 enhanced MR neurography (ICC 0.72 and 0.90). Mean SNR was significantly higher in Ferumoxtran\u201010\u2010enhanced MRN for all analyzed structures, while mean CNR was for significantly better for S1 ganglion and femoral nerve in Ferumoxtran\u201010\u2010enhanced MRN (p<\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Data Conclusion<\/jats:title>Ferumoxtran\u201010\u2010enhanced MRN of the LS plexus showed significantly higher image quality and nerve visibility with better vascular suppression as compared to Gd\u2010enhanced MRN.<\/jats:p><\/jats:sec>Evidence Level<\/jats:title>2<\/jats:p><\/jats:sec>Technical Efficacy<\/jats:title>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29604","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T07:29:55Z","timestamp":1725434995000},"page":"1677-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Delayed Ferumoxtran\u201010\u2010Enhanced Magnetic Resonance Neurography of the Lumbosacral Plexus: Impact on Vascular Suppression and Image Quality"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-8415","authenticated-orcid":false,"given":"Malwina","family":"Kaniewska","sequence":"first","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ) Zurich Switzerland"},{"name":"University of Zurich (UZH) Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7539-6033","authenticated-orcid":false,"given":"Eva","family":"Deininger\u2010Czermak","sequence":"additional","affiliation":[{"name":"University of Zurich (UZH) Zurich Switzerland"},{"name":"Department of Nuclear Medicine University Hospital Zurich Zurich Switzerland"},{"name":"Department of Forensic Medicine and Imaging, Institute of Forensic Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Ensle","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ) Zurich Switzerland"},{"name":"University of Zurich (UZH) Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivio F.","family":"Donati","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ) Zurich Switzerland"},{"name":"University of Zurich (UZH) Zurich Switzerland"},{"name":"Radiologie Hirslanden Zurich, Octorad AG Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Guggenberger","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ) Zurich Switzerland"},{"name":"University of Zurich (UZH) Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28296"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3552-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4879"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-019-03321-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109304"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000434"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221087"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-021-03804-w"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(95)00024-B"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27405"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:03:36Z","timestamp":1741763016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jmri.29604"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29604","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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