{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:56:42Z","timestamp":1769507802918,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871341"],"award-info":[{"award-number":["81871341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030027"],"award-info":[{"award-number":["82030027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101149"],"award-info":[{"award-number":["82101149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101219"],"award-info":[{"award-number":["82101219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271945"],"award-info":[{"award-number":["82271945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary open\u2010angle glaucoma (POAG), a leading cause of irreversible blindness, is associated with neurodegeneration in the visual pathway, but the underlying pathophysiology remains incompletely resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize macro\u2010 and microstructural white matter abnormalities in optic tract (OT) and optic radiation (OR) of POAG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Populations<\/jats:title><jats:p>A total of 34 POAG patients (21 males, 13 females) and 25 healthy controls (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>) (16 males, nine females).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T; multiband spin\u2010echo echo planar diffusion spectrum imaging (DSI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>We compared multiple morphology metrics, including volume, area, length, and shape metrics, as well as diffusion metrics such as diffusion tensor imaging (fractional anisotropy [FA], mean diffusivity, radial diffusivity, and axial diffusivity), mean apparent propagator (mean squared displacement, q\u2010space inverse variance, return\u2010to\u2010origin probability, return\u2010to\u2010axis probabilities [RTAP] and return\u2010to\u2010plane probabilities, non\u2010Gaussianity, perpendicular non\u2010Gaussianity, parallel non\u2010Gaussianity), and neurite orientation dispersion and density imaging (intracellular volume fraction, orientation dispersion index [ODI], and isotropic volume fraction of the OT and OR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Statistical comparisons and classifications employed linear mixed model and logistic regression. Diagnostic performance was assessed using area under the receiver operating characteristic curve (AUC). <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 was statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphology analysis in POAG revealed a lower span in the OR (29.43\u2009\u00b1\u20092.30 vs. 30.59\u2009\u00b1\u20092.01, 3.8%) and OT (19.73\u2009\u00b1\u20092.21 vs. 20.68\u2009\u00b1\u20091.37, 4.6%), and a higher curl (3.03\u2009\u00b1\u20090.22 vs. 2.90\u2009\u00b1\u20090.16, 4.5%) in OT. Diffusion metrics revealed lower mean FA (OR: 0.328\u2009\u00b1\u20090.03 vs. 0.340\u2009\u00b1\u20090.018, 3.5%; OT: 0.255\u2009\u00b1\u20090.022 vs. 0.268\u2009\u00b1\u20090.018, 4.9%) and lower mean RTAP (OR: 5.919\u2009\u00b1\u20090.529 vs. 6.216\u2009\u00b1\u20090.489, 4.8%; OT: 4.089\u2009\u00b1\u20090.402 vs. 4.280\u2009\u00b1\u20090.353, 4.5%), with higher mean ODI in the OT (0.448\u2009\u00b1\u20090.029 vs. 0.433\u2009\u00b1\u20090.025, 3.5%). Combined models, incorporating these MRI metrics, effectively discriminated POAG from HCs, achieving AUCs of 0.84 for OR and 0.83 for OT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusions<\/jats:title><jats:p>DSI\u2010derived morphology and diffusion metrics demonstrated macro\u2010 and micro abnormalities in the visual pathway, providing insights into POAG\u2010related neurodegeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29616","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T13:56:24Z","timestamp":1727099784000},"page":"1699-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing Visual Pathway White Matter Degeneration in Primary Open\u2010Angle Glaucoma Using Multiple <scp>MRI<\/scp> Morphology and Diffusion Metrics"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4138-996X","authenticated-orcid":false,"given":"Linying","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye and ENT Hospital Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University  Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-4083","authenticated-orcid":false,"given":"Jingfeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-0027","authenticated-orcid":false,"given":"Rifeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Fujian Union Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye and ENT Hospital Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University  Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-5905","authenticated-orcid":false,"given":"Zuohua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye and ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19838"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.09.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000511"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5682"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27447"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117329"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02464-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081240"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198830"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1122-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00426"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy338"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.027"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"756","article-title":"Microstructural visual pathway white matter alterations in primary open\u2010angle glaucoma: A neurite orientation dispersion and density imaging study","volume":"43","author":"Haykal S","year":"2022","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.2.29"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29202"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0949"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.817070"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09505-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.19"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01185-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0663-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.027"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2045126"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001241"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-38062-4_4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237587"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.016"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01285-x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.01.014"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00400-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0399-0"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afres.2022.100250"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04445-6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.01.017"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.046"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.563595"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073935"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:06:30Z","timestamp":1741763190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jmri.29616"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29616","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}