{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:29:27Z","timestamp":1791822567941,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background<\/jats:title>\n Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of the heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To determine the reproducibility of in vivo cardiac multifrequency MRE (MMRE) for assessing diastolic left ventricular (LV) stiffness and viscosity.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n This single\u2010center study included a total of 28 participants (mean age, 56.6\u2009\u00b1\u200923.0\u2009years; 16 male) consisting of randomly selected healthy participants (mean age, 44.6\u2009\u00b1\u200920.1\u2009years; 9 male) and patients with aortic stenosis (mean age, 78.3\u2009\u00b1\u20093.8\u2009years; 7 male).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2009T, 3D multifrequency MRE with a single\u2010shot spin\u2010echo planar imaging sequence.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Each participant underwent two cardiac MMRE examinations on the same day. Full 3D wave fields were acquired in diastole at frequencies of 80, 90, and 100\u2009Hz during a total of three breath\u2010holds. Shear wave speed (SWS) and penetration rate (PR) were reconstructed as a surrogate for tissue stiffness and inverse viscous loss. Epicardial and endocardial ROIs were manually drawn by two independent readers to segment the LV myocardium.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Shapiro\u2013Wilk test, Bland\u2013Altman analysis and intraclass correlation coefficient (ICC).\n P<\/jats:italic>\n \u2010value <0.05 were considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Bland\u2013Altman analyses and intraclass correlation coefficients (ICC\u2009=\u20090.96 for myocardial stiffness and ICC\u2009=\u20090.93 for viscosity) indicated near\u2010perfect test\u2013retest repeatability among examinations on the same day. The mean SWS for scan and re\u2010scan diastolic LV myocardium were 2.42\u2009\u00b1\u20090.24\u2009m\/s and 2.39\u2009\u00b1\u20090.23\u2009m\/s; the mean PR were 1.24\u2009\u00b1\u20090.17\u2009m\/s and 1.22\u2009\u00b1\u20090.14\u2009m\/s. Inter\u2010reader variability showed good to excellent agreement for myocardial stiffness (ICC\u2009=\u20090.92) and viscosity (ICC\u2009=\u20090.85).<\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Cardiac MMRE is a promising and reproducible method for noninvasive assessment of diastolic LV stiffness and viscosity.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n 1<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.29640","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T03:06:05Z","timestamp":1729825565000},"page":"2146-2154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Reproducibility of Cardiac Multifrequency\n MR<\/scp>\n Elastography in Assessing Left Ventricular Stiffness and Viscosity"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-7660","authenticated-orcid":false,"given":"Johannes","family":"Castelein","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Duus","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille S.","family":"B\u00e6kke","sequence":"additional","affiliation":[{"name":"The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingolf","family":"Sack","sequence":"additional","affiliation":[{"name":"Department of Radiology Charite\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias S.","family":"Anders","sequence":"additional","affiliation":[{"name":"Department of Radiology Charite\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kettless","sequence":"additional","affiliation":[{"name":"Deparment of Research and Collaboration Siemens Healthcare A\/S Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam E.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi A. J. O.","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[{"name":"The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels G.","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten A. V.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"The Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1243","authenticated-orcid":false,"given":"Ronald J. H.","family":"Borra","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Nuclear Medicine and Molecular Imaging University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42254-022-00543-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000198"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26101"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25760"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22467"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-021-00007-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.716886"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.07.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.218271"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181ec4b63"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000892"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-60"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13131605"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24185"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-44"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22531"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01232-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29320"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2016.01.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2024.05.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2017.1278689"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21878"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000704"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22144"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T09:57:22Z","timestamp":1744365442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jmri.29640"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29640","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"2024-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}