{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:28:25Z","timestamp":1770679705965,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["R01HL162353"],"award-info":[{"award-number":["R01HL162353"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["R56HL162699"],"award-info":[{"award-number":["R56HL162699"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["S10OD018482\u201001"],"award-info":[{"award-number":["S10OD018482\u201001"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Modified Look\u2010Locker imaging (MOLLI) T1 mapping sequences are acquired during breath\u2010holding and require ECG gating with consistent R\u2010R intervals, which is problematic for patients with atrial fibrillation (AF). Consequently, there is a need for a free\u2010breathing and ungated framework for cardiac T1 mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop and evaluate a free\u2010breathing ungated radial simultaneous multi\u2010slice (SMS) cardiac T1 mapping (FURST) framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective, nonconsecutive cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010four datasets from 17 canine and 7 human subjects (4 males,  years; 3 females,  years). Canines were from studies involving AF induction and ablation treatment. The human population included separate subjects with suspected microvascular disease, acute coronary syndrome with persistent AF, and transthyretin amyloidosis with persistent AF. The remaining human subjects were healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Pre\u2010 and post\u2010contrast T1 mapping with the free\u2010breathing and ungated SMS inversion recovery sequence with gradient echo readout and with conventional MOLLI sequences at 1.5\u2009T and 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>MOLLI and FURST were acquired in all subjects, and American Heart Association (AHA) segmentation was used for segment\u2010wise analysis. Pre\u2010contrast T1, post\u2010contrast T1, and ECV were analyzed using correlation and Bland\u2013Altman plots in 13 canines and 7 human subjects. T1 difference box plots for repeated acquisitions in four canine subjects were used to assess reproducibility. The PIQUE image quality metric was used to evaluate the perceptual quality of T1 maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Paired t\u2010tests were used for all comparisons between FURST and MOLLI, with  indicating statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between FURST and MOLLI pre\u2010contrast T1 reproducibility ( and , ), FURST and MOLLI ECV ( and , ), or FURST and MOLLI PIQUE scores ( and , ). The ECV mean difference was  with .<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FURST had similar quality pre\u2010contrast T1, post\u2010contrast T1, and ECV maps and similar reproducibility compared to MOLLI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29676","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:18:42Z","timestamp":1733944722000},"page":"2587-2600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Free\u2010Breathing Ungated Radial Simultaneous Multi\u2010Slice Cardiac <scp>T1<\/scp> Mapping"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-7691","authenticated-orcid":false,"given":"Johnathan V.","family":"Le","sequence":"first","affiliation":[{"name":"Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences University of Utah  Salt Lake City Utah USA"},{"name":"Department of Biomedical Engineering University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason K.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Sideris","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Bieging","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward V. 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