{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:50:46Z","timestamp":1791946246932,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82327803"],"award-info":[{"award-number":["82327803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825012"],"award-info":[{"award-number":["81825012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151309"],"award-info":[{"award-number":["82151309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271952"],"award-info":[{"award-number":["82271952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Middle cerebral artery (MCA) stenosis affects lenticulostriate arteries (LSAs) that supply the basal ganglia. Increased spatial resolution and signal\u2010to\u2010noise ratio of 7\u2009T could facilitate morphological imaging of very\u2010small\u2010diameter LSAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate differences in morphological characteristics of LSA among different MCA stenoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>We enrolled 161 patients (age: 26\u201383\u2009years, 115 males) with MCA\u2010M1\u2010segment stenosis, and assigned them to the symptomatic (ischemic stroke on imaging, or transient ischemic attack diagnosed clinically within 90\u2009days) and asymptomatic (mild\u2010to\u2010moderate stenosis, \u226470% diameter reduction and severe stenosis, &gt;70% and\u2009\u226499% diameter reductions) groups and further subdivided them into the proximal and distal stenosis subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>7\u2009T, three\u2010dimensional time\u2010of\u2010flight magnetic resonance angiography (<jats:styled-content style=\"fixed-case\">3D TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The number of LSA stems, branches, length, and tortuosity (LSA length\/linear distance between LSA start\u2010 and endpoints) were evaluated independently in both hemispheres by 3 radiologists with 2\u2010, 10\u2010, and 12\u2010years' experience, and inter\u2010group and inter\u2010subgroup comparisons were undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Independent <jats:italic>t<\/jats:italic> tests, paired <jats:italic>t<\/jats:italic> tests, chi\u2010square test, and multiple linear regression analysis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 indicated statistical significance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the asymptomatic group (<jats:italic>N<\/jats:italic>\u2009=\u200976), the symptomatic group (<jats:italic>N<\/jats:italic>\u2009=\u200985) had significantly fewer LSA branches (7.58\u2009\u00b1\u20092.31 vs. 9.29\u2009\u00b1\u20092.37) and shorter length (4.32\u2009\u00b1\u20090.84 vs. 4.59\u2009\u00b1\u20090.72\u2009cm). There were no significant intergroup differences in LSA morphological characteristics between the mild\u2010to\u2010moderate and severe\u2010stenosis subgroups (LSA stems: <jats:italic>P<\/jats:italic>\u2009=\u20090.457, LSA branches: <jats:italic>P<\/jats:italic>\u2009=\u20090.433, LSA length: <jats:italic>P<\/jats:italic>\u2009=\u20090.150, and LSA tortuosity: <jats:italic>P<\/jats:italic>\u2009=\u20090.613). The proximal stenosis subgroup had significantly fewer (8.08\u2009\u00b1\u20091.80 vs. 10.64\u2009\u00b1\u20092.21) and shorter LSA branches (4.43\u2009\u00b1\u20090.69 vs. 4.76\u2009\u00b1\u20090.71\u2009cm) than in the distal stenosis subgroup. Multiple linear regression, after false discovery rate correction, showed that symptoms and the MCA\u2010M1\u2010segment\u2010stenosis site (proximal\/distal) were significantly associated with LSA and length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Having symptoms and a proximal MCA\u2010M1 segment stenosis were associated with fewer LSA branches, whereas stenosis severity did not significantly affect LSA morphological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Lenticulostriate arteries mainly originate from the middle cerebral artery, which 7\u2009T magnetic resonance imaging (MRI) can help visualize effectively. We mainly focused on evaluating lenticulostriate artery stems, branches, length, and tortuosity (length\/linear distance between start\u2010 and endpoints) among 3 types of middle cerebral artery stenoses (symptomatic and asymptomatic, mild\u2010to\u2010moderate and severe stenosis, and proximal and distal stenosis). Symptomatic patients with proximal MCA stenosis had fewer lenticulostriate artery branches (7.58\u2009\u00b1\u20092.31 vs. 9.29\u2009\u00b1\u20092.37 and 8.08\u2009\u00b1\u20091.80 vs. 10.64\u2009\u00b1\u20092.21). This research based on the morphological perspective clearly depicted the lenticulostriate artery using 7\u2009T MRI to provide more intuitive results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29693","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:25:08Z","timestamp":1736414708000},"page":"201-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Morphological Study on Lenticulostriate Arteries in Patients With Middle Cerebral Artery Stenosis at 7\u2009T <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"62","author":[{"given":"Runze","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, the First Medical Center Chinese PLA General Hospital  Beijing 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