{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:51:32Z","timestamp":1751629892826,"version":"3.41.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3507004"],"award-info":[{"award-number":["2023YFB3507004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20148","52377228","52407262"],"award-info":[{"award-number":["U21A20148","52377228","52407262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085QE181"],"award-info":[{"award-number":["2308085QE181"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatic damage is a common digestive system disease with no specific drugs. Static magnetic field (SMF), the key component of magnetic resonance imaging (MRI), has demonstrated prominent effects in various disease models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the effects of 0.1\u20139.4\u2009T SMFs on pancreatic injury induced by alcohol, and acute pancreatitis (AP) induced by L\u2010arginine (L\u2010Arg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Twelve healthy C57BL\/6J male mice, 30 AP model male mice, and 30 alcohol\u2010associated liver disease (AALD) model male mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5\u20139.4\u2009T SMFs for 12\u2009hours and 0.1\u2009T SMF for 72\u2009hours. No imaging sequence was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Histological analysis on AALD mice pancreas was conducted. For L\u2010Arg\u2010induced AP mice, their body weight, food\/water consumption, open field behavior, blood analysis, as well as histological analysis, inflammatory, oxidative stress of the pancreas were measured. In vitro cellular experiments were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Data are presented as means\u2009\u00b1\u2009SD and analyzed using the two\u2010tailed Student's <jats:italic>t<\/jats:italic>\u2010test or one\u2010way analysis of variance (ANOVA) test. <jats:italic>P<\/jats:italic> values &lt;0.05 were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1.5\u20137\u2009T SMFs significantly reduced alcohol\u2010induced pancreatic damage, increasing the structurally intact acinar area from 51.5% to 78.3%, whereas the effect of 9.4\u2009T SMF is not obvious. 0.1\u2009T SMF can reduce the AP mice lethality, increase the structurally intact acinar area from 31.0% to 59.7%, associated with the reduced pancreatic inflammatory responses (78.1% reduction of F4\/80 and 80.0% reduction of MPO), 20.0% decreased oxidative stress and 53.2% reduced pancreatic cell apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>High\u2010field MRI may be safe for pancreatic\u2010related diseases at the animal level. SMFs have a future potential to be developed as non\u2010invasive and highly penetrating physical modalities for the treatment of pancreatic injury including AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>This study aims to evaluate the safety and potential therapeutic effects of moderate\u2010 to high\u2010intensity static magnetic fields (SMFs) on mice with pancreatic injury. Their findings revealed that SMFs between 1.5 and 7 Tesla (T) helped reduce alcohol\u2010induced pancreatic damage, while a stronger 9.4\u2009T showed no effect. Interestingly, for mice with L\u2010arginine\u2010induced acute pancreatitis, a weaker 0.1\u2009T significantly increased the area of healthy acinar cells from 31.0% to 59.7%. These results not only suggest that MRI\u2010related SMFs are safe for pancreatic diseases in animals, but also unravel the potential of SMFs as a future treatment option for pancreatic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>N\/A<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29704","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:41:27Z","timestamp":1736415687000},"page":"244-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effects of Moderate to High Static Magnetic Fields on Pancreatic Damage"],"prefix":"10.1002","volume":"62","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"},{"name":"Science Island Branch of Graduate School University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Chen","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"},{"name":"Institutes of Physical Science and Information Technology Anhui University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-2189","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"},{"name":"Science Island Branch of Graduate School University of Science and Technology of China  Hefei China"},{"name":"Institutes of Physical Science and Information Technology Anhui University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020190"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31310-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195565"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0158-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3976.1151"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-50-591-188"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597854"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.072"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05976-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29297"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120398"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27496"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010108"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010073"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0097"},{"issue":"1","key":"e_1_2_7_18_1","article-title":"A static magnetic field improves iron metabolism and prevents high\u2010fat\u2010diet\/streptozocin\u2010induced diabetes","volume":"2","author":"Yu B","year":"2021","journal-title":"Innovation"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2023.410"},{"key":"e_1_2_7_20_1","first-page":"41","article-title":"Endogenous iron biomineralization in the mouse spleen of metabolic diseases","volume":"13","author":"Guo R","year":"2024","journal-title":"Fundam Res"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2022.460"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100417"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002645"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.143"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20154-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c05003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.724514"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i7.728"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102175"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0227302"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101103"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22911"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.379"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.29704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T03:24:29Z","timestamp":1750389869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.29704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jmri.29704"],"URL":"https:\/\/doi.org\/10.1002\/jmri.29704","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}