{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:25:41Z","timestamp":1783574741971,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7212126"],"award-info":[{"award-number":["7212126"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171927"],"award-info":[{"award-number":["82171927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton density fat fraction (PDFF) and R2* are noninvasive MRI biomarkers for quantifying fat and iron in abdominal organs. While 3.0\u2009T MRI is widely used clinically, 5.0\u2009T may offer improved accuracy and reliability. With the increasing availability of 5.0\u2009T, assessing its feasibility and utility for quantifying PDFF and R2* in abdominal organs is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the agreement of the PDFF and R2* in the liver, pancreas, kidney, and paraspinal muscle at 2 different field strengths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 127 participants, including 60 healthy volunteers and 67 with metabolic dysfunction\u2010associated steatotic liver disease (100 women and 27 men, 52\u2009\u00b1\u20099\u2009years old).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T and 5.0\u2009T; Chemical shift\u2010encoded multi\u2010echo gradient echo sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>PDFF and R2* values in the liver, pancreas, kidney, and paraspinal muscle were measured by three observers to evaluate the interobserver and interfield agreement using two 3.0\u2009T scanners (scanner 1 and scanner 2) and one 5.0\u2009T scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Linear regression, Bland\u2013Altman analyses, and intraclass correlation coefficients (ICCs). The <jats:italic>p<\/jats:italic>\u2010value &lt;\u20090.05 indicated statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PDFF and R2* at 5.0\u2009T were strongly correlated with those at two 3.0\u2009T scanners for all organs (<jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u20090.905\u20130.998 for PDFF; 0.831\u20130.991 for R2*), indicating high interfield ICCs (0.892\u20130.993 for PDFF; 0.910\u20130.981 for R2*). Comparisons between 5.0\u2009T and two 3.0\u2009T scanners showed good interfield agreement for PDFF (mean bias, \u22120.57% to 0.03%) while a higher bias for R2* (mean bias, \u221216.53 to \u22122.64\u2009s<jats:sup>\u22121<\/jats:sup>, 95% LoA, \u221234.28 to 1.21\u2009s<jats:sup>\u22121<\/jats:sup>) at 5.0\u2009T compared to the comparison between 3T scanners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>5.0\u2009T revealed high interfield agreement between the PDFF and R2* with 3.0\u2009T, which could provide reliable quantification of fat and iron contents in abdominal organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29743","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:13:01Z","timestamp":1744279981000},"page":"551-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantification of the Proton Density Fat Fraction and Iron Content: A Comparative Study Between 3.0\u2009T and 5.0\u2009T <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"62","author":[{"given":"Yali","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing 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