{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:30:49Z","timestamp":1789576249681,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), the most common dystrophinopathies, require distinct treatments. Corticosteroids are effective for DMD but less so for BMD. Early diagnosis can improve DMD outcomes and prevent BMD overtreatment. However, differentiating them in younger children with mild symptoms is challenging due to overlapping features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the performance of multi\u2010parametric quantitative MRI (qMRI) in early differentiation between BMD and DMD, particularly among younger patients in the mild disease stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>121 DMD males (mean age 8.5\u2009\u00b1\u20091.6\u2009years), 28 BMD males (9.7\u2009\u00b1\u20093.3\u2009years), and 26 male healthy controls (HCs) (9.4\u2009\u00b1\u20092.7\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T\/3\u2010point Dixon (fast\u2010spin\u2010echo), T1\u2010mapping (modified\u2010Look\u2010Locker\u2010inversion\u2010recovery), and T2\u2010mapping (balance\u2010steady\u2010state\u2010free\u2010precession).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>qMRI measurements (fat fraction [FF], T1, and T2) in 18 pelvic and thigh muscles were conducted. A linearized NorthStar ambulatory assessment (NSAA) score was used to evaluate the function status, with a mild functional decline stage defined as a score of 76\u2013100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Mann\u2013Whitney test, Kruskal\u2013Wallis test, and Receiver operating characteristic curves. A <jats:italic>P<\/jats:italic>\u2010value &lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all subject groups, DMD exhibits significantly higher FF and T2 and lower T1 compared to BMD. The max differences in mean FF, T1, and T2 was 45.29%, 543\u2009ms, and 31.0\u2009ms, respectively. Overall, the area under curve (AUC) values for FF surpassed those for T2 and T1 in the majority of muscles. In the mild subgroup below 10\u2009years old, DMD had significantly higher FF and T1 than BMD. The combination of FF and T1 in gluteus medius, rectus femoris, vastus lateralis, vastus intermedius, vastus medialis, and adductor magnus achieved higher AUCs (0.816\u20130.957) than FF (0.773\u20130.862) or T1 (0.701\u20130.819) in differentiating the two subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Multi\u2010parametric qMRI demonstrates potential as an effective tool for early differentiation between DMD and BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29755","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:04:44Z","timestamp":1741712684000},"page":"457-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi\u2010Parametric Quantitative MRI in the Early Differential Diagnosis of Ambulatory Children With Duchenne Muscular Dystrophy and Becker Muscular Dystrophy"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6917-0895","authenticated-orcid":false,"given":"Fei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Hengyang Medical School University of South China  Hengyang China"},{"name":"Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-6142","authenticated-orcid":false,"given":"Huayan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neurology West China Second University Hospital, Sichuan University  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