{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:16:13Z","timestamp":1791569773987,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K15836"],"award-info":[{"award-number":["21K15836"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imaging biomarkers for neuropsychiatric systemic lupus erythematosus (NPSLE) are highly needed, and intracranial contrast\u2010enhanced vessel wall imaging (CE\u2010VWI) can potentially detect cerebral vessel wall abnormalities in lupus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the diagnostic value of CE\u2010VWI in differentiating NPSLE from non\u2010NPSLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cross\u2010sectional, retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Forty\u2010seven patients with NPSLE (mean age, 44.3\u2009years\u2009\u00b1\u200913.2 standard deviation [SD], 40 females, 85%) and 52 patients without NPSLE (mean age, 43.0\u2009years\u2009\u00b1\u200916.5 SD, 49 females, 89%). The non\u2010NPSLE group consisted of SLE patients who had no NP symptoms or were diagnosed with comorbidities from other diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T, three\u2010dimensional (3D) contrast\u2010enhanced vessel wall imaging (3D\u2010T1\u2010CUBE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Vessel wall lesions (VWLs) were visually assessed across 15 segments, from the internal carotid artery and basilar artery to A1\u2013A2 for ACA, M1\u2013M2 for MCA, and P1\u2013P2 for PCA, for wall thickening and enhancement. Conventional MRI and MR angiography were also used to assess infarction, hemorrhage, atrophy, and arterial stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Paired comparisons using the chi\u2010square and unpaired <jats:italic>t<\/jats:italic>\u2010tests were followed by multivariate logistic regression analysis incorporating factors with significant group differences to identify associations with NPSLE. Receiver operating characteristic (ROC) analysis with the area under the curve (AUC) assessed the diagnostic performance of CE\u2010VWI. A <jats:italic>p\u2010<\/jats:italic>value &lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NPSLE group showed a significantly higher number of contrast\u2010enhancing VWLs (CE\u2010VWLs; median [interquartile range]: 2 [0.5\u20134] vs. 0 [0\u20131]). Cerebral infarctions and arterial stenotic lesions were more common in NPSLE, occurring in 12 (26%) vs. 2 (3%) and 19 (40%) vs. 5 (9%) of patients, respectively. A multivariate logistic regression analysis identified CE\u2010VWLs as the sole significant factor associated with NPSLE (odds ratio, 1.97; 95% confidence interval, 1.23\u20133.16). The ROC analysis showed an AUC of 0.78 for CE\u2010VWLs, with a sensitivity of 60% and a specificity of 87%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>CE\u2010VWI may demonstrate high specificity and good diagnostic performance in differentiating NPSLE from non\u2010NPSLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29810","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:25:06Z","timestamp":1747117506000},"page":"1021-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Diagnostic Value of Contrast\u2010Enhanced Vessel Wall <scp>MRI<\/scp> for Diagnosing Neuropsychiatric Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-6736","authenticated-orcid":false,"given":"Satoru","family":"Ide","sequence":"first","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Fujita","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Futatsuya","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Oku","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-110X","authenticated-orcid":false,"given":"Takatoshi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0534-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313512540"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3645"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.11.001"},{"key":"e_1_2_9_8_1","volume-title":"Osborn's Brain e\u2010Book","author":"Osborn A. 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