{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:53:44Z","timestamp":1783947224183,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R352\u2010A20745"],"award-info":[{"award-number":["R352\u2010A20745"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE\u2010derived parameters, including the storage modulus (<jats:italic>G<\/jats:italic>') and the magnitude of the complex modulus (|<jats:italic>G<\/jats:italic>*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose\/Hypothesis<\/jats:title><jats:p>To evaluate the repeatability of <jats:italic>G<\/jats:italic>' and |<jats:italic>G<\/jats:italic>*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population\/Subjects<\/jats:title><jats:p>Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64\u2009\u00b1\u200912\u2009years, 10 females) scheduled for resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>MRE was performed on a 3\u2009T system using a single\u2010shot spin\u2010echo echo\u2010planar imaging (SE\u2010EPI) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Tumors were segmented on contrast\u2010enhanced T1\u2010weighted images; distance and volume metrics were extracted. Regions of interest were applied to <jats:italic>G<\/jats:italic>' and |<jats:italic>G<\/jats:italic>*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median <jats:italic>G<\/jats:italic>' or |<jats:italic>G<\/jats:italic>*| values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed\u2010rank test evaluated ranking stability and scan\u2010rescan CV%. Statistical significance was defined as <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference in CV% G' (14.89\u2009\u00b1\u200912.32) and CV% |<jats:italic>G<\/jats:italic>*| (13.88\u2009\u00b1\u200912.60) was not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.61). Tumor volume inversely correlated with CV% (<jats:italic>G<\/jats:italic>': <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.75 |<jats:italic>G<\/jats:italic>*|: <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.59). Tumor\u2010EOP distance had no significant effect (<jats:italic>G<\/jats:italic>': <jats:italic>p<\/jats:italic>\u2009=\u20090.58, |<jats:italic>G<\/jats:italic>*|: <jats:italic>p<\/jats:italic>\u2009=\u20090.23). Rankings remained stable (<jats:italic>G<\/jats:italic>': <jats:italic>p<\/jats:italic>\u2009=\u20090.82, |<jats:italic>G<\/jats:italic>*|: <jats:italic>p<\/jats:italic>\u2009=\u20090.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MRE\u2010derived parameters are repeatable in intracranial meningiomas, with <jats:italic>G<\/jats:italic>' and |<jats:italic>G<\/jats:italic>*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.29825","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:30:29Z","timestamp":1747301429000},"page":"1047-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Repeatability of Magnetic Resonance Elastography\u2010Derived Mechanical Parameters in Intracranial Meningiomas"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-6344","authenticated-orcid":false,"given":"Jan Saip","family":"Aunan\u2010Diop","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark, BRIDGE (Brain Research Inter Disciplinary Guided Excellence), University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-230X","authenticated-orcid":false,"given":"Ancuta Ioana","family":"Friismose","sequence":"additional","affiliation":[{"name":"Department of Radiology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-4490","authenticated-orcid":false,"given":"Bo","family":"Halle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark, BRIDGE (Brain Research Inter Disciplinary Guided Excellence), University of Southern Denmark  Odense 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