{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:11:28Z","timestamp":1780449088173,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471971"],"award-info":[{"award-number":["82471971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, and accurate assessment is required for diagnosis and management. Goldmann applanation tonometry (GAT) requires corneal contact, whereas non\u2010contact tonometry (NCT) is susceptible to ocular geometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate three\u2010dimensional MR elastography (3D\u2010MRE) as a non\u2010invasive method for IOP assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty\u2010nine healthy volunteers (13 females and 16 males, median age: 33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Phase\u2010contrast spin\u2010echo echo planar MRE at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>IOP measured by GAT (IOP<jats:sub>GAT<\/jats:sub>) and NCT (IOP<jats:sub>NCT<\/jats:sub>) was obtained. Ocular geometry parameters (central corneal thickness [CCT], mean keratometry [Km], axial length [AL], anterior chamber depth [ACD], and lens thickness [LT]) were measured by optical biometry. The first 10 subjects underwent repeated MRE at 60, 90, and 120\u2009Hz to assess test\u2013retest repeatability, and 90\u2009Hz was used in subsequent acquisitions. Three readers (S.Y., G.Z., and Z.Y., with 12, 3, and 3\u2009years of experiences in MRE, respectively) independently assessed shear stiffness (SS) of the anterior segment and whole eye to evaluate test\u2013retest repeatability and inter\u2010\/intra\u2010observer agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Wilcoxon signed rank test; multivariable regression; intraclass correlation coefficient (ICC); Spearman's correlation; Significance level: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SS@90\u2009Hz of the anterior segment (SS\u2010AS@90\u2009Hz) demonstrated excellent repeatability and inter\u2010\/intra\u2010observer agreement (all ICC \u2265\u20090.889). IOP<jats:sub>GAT<\/jats:sub> demonstrated a stronger correlation with SS\u2010AS@90\u2009Hz (<jats:italic>r<\/jats:italic>\u2009=\u20090.64) than with IOP<jats:sub>NCT<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u20090.59). Multivariable regression identified SS\u2010AS@90\u2009Hz (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.53) and IOP<jats:sub>NCT<\/jats:sub> (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.40) as independent predictors of IOP<jats:sub>GAT<\/jats:sub>, collectively explaining 58.3% of the variance. No correlation between SS\u2010AS@90\u2009Hz and CCT (<jats:italic>p<\/jats:italic>\u2009=\u20090.10), Km (<jats:italic>p<\/jats:italic>\u2009=\u20090.67), ACD (<jats:italic>p<\/jats:italic>\u2009=\u20090.90), or LT (<jats:italic>p<\/jats:italic>\u2009=\u20090.82) was found, while a significant correlation with AL (<jats:italic>r<\/jats:italic>\u2009=\u20090.02) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>SS\u2010AS@90\u2009Hz was identified as a robust biomarker for predicting IOP, independent of most ocular geometric parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.70040","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T19:24:37Z","timestamp":1753298677000},"page":"1483-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Intraocular Pressure Using Three\u2010Dimensional <scp>MR<\/scp> Elastography in Ophthalmologically Normal Individuals"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7976-1597","authenticated-orcid":false,"given":"Zheng","family":"Gai","sequence":"first","affiliation":[{"name":"Department of Radiology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology Shengjing Hospital of China Medical University  Shenyang 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