{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:08:36Z","timestamp":1785290916312,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371931"],"award-info":[{"award-number":["82371931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085MC056"],"award-info":[{"award-number":["2408085MC056"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporal lobe (TL) damage is a common complication of radiotherapy (RT) for nasopharyngeal carcinoma (NPC), yet early morphological changes during RT remain poorly characterized. Identifying these early changes could facilitate timely interventions to mitigate long\u2010term cognitive impairments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To characterize early TL structural changes during RT using cortical thickness (CTh) and cortical mean diffusivity (cMD), and to explore potential dose\u2010dependent relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective, longitudinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>40 patients with NPC (5 females, 12.5%, mean age 52.7\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2009T, diffusion tensor imaging (DTI) (spin echo echo\u2010planar imaging sequence); T1\u2010weighted images (magnetization\u2010prepared rapid gradient echo (MPRAGE) sequence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>\n                      MRI was acquired at three phases: pre\u2010treatment (tp\n                      <jats:sub>1<\/jats:sub>\n                      ), mid\u2010treatment (tp\n                      <jats:sub>2<\/jats:sub>\n                      ), and post\u2010treatment (tp\n                      <jats:sub>3<\/jats:sub>\n                      ). At each time point, CTh and cMD were quantified from 18 bilateral TL regions defined by the Desikan\u2010Killiany atlas using surface\u2010based analysis. Radiation dose was mapped onto these regions using CT\u2010MRI co\u2010registration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Linear mixed\u2010effects models assessed cortical changes across treatment phases (tp\n                      <jats:sub>1<\/jats:sub>\n                      \u2013tp\n                      <jats:sub>2<\/jats:sub>\n                      [P1], tp\n                      <jats:sub>2<\/jats:sub>\n                      \u2013tp\n                      <jats:sub>3<\/jats:sub>\n                      [P2], tp\n                      <jats:sub>1<\/jats:sub>\n                      \u2013tp\n                      <jats:sub>3<\/jats:sub>\n                      [P3]). Dose\u2013response relationships were evaluated using Pearson correlations and permutation testing. Family\u2010wise error (FWE) correction (Bonferroni method) was applied, with significance set at corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across treatment, cMD significantly increased while CTh significantly decreased, particularly evident at the final post\u2010treatment phase (P3: CTh in 15\/18 regions; cMD in 8\/18 regions). Early significant changes (P1) appeared in fewer regions (CTh: 3\/18; cMD: 5\/18). Dose\u2010dependent analysis revealed small\u2010to\u2010moderate correlations; after strict FWE correction, significant associations remained only in the right banks of the superior temporal sulcus (cMD,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.57) and left inferior temporal gyrus (CTh,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.44) at P1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>RT\u2010induced TL structural changes emerge early and intensify progressively. Despite limited statistical power, the early dose associations highlight the need for larger studies to further elucidate early dose\u2013response dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence\u2009Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70052","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:29:47Z","timestamp":1753082987000},"page":"1686-1697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Temporal Cortex Changes During Radiotherapy in Cortical Mean Diffusivity and Thickness Derived From\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"62","author":[{"given":"Chuangwei","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology Hefei Institutes of Physical Science, Chinese Academy of Sciences  Hefei China"},{"name":"Research Center of Clinical Medical Imaging  Hefei China"},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology Hefei Institutes of Physical Science, Chinese Academy of Sciences  Hefei China"},{"name":"University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong","family":"Cao","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology Hefei Institutes of Physical Science, Chinese Academy of Sciences  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